Cytokines & Chemokines

Recombinant Murine PF-4 (CXCL4) (Legacy Tebubio ref. 167250-39). PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the alpha-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes, and has been shown to inhibit angiogenesis. Recombinant Murine PF-4 is an 8.2 kDa protein containing 76 amino acid residues, including the four highly conserved residues present in CXC chemokines.

Recombinant Murine TARC (CCL17) (Legacy Tebubio ref. 167250-43). TARC, a CC chemokine, is predominantly produced by dendritic cells in the thymus, and signals through the CCR4 receptor. TARC is chemotactic towards T cells. Recombinant Murine TARC (CCL17) is an 7.9 kDa protein containing 70 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

Recombinant Murine TARC (CCL17) (Legacy Tebubio ref. 167250-43). TARC, a CC chemokine, is predominantly produced by dendritic cells in the thymus, and signals through the CCR4 receptor. TARC is chemotactic towards T cells. Recombinant Murine TARC (CCL17) is an 7.9 kDa protein containing 70 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

Recombinant Murine BRAK (CXCL14) (Legacy Tebubio ref. 167250-45). Breast and Kidney‐expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP‐2 alpha and beta. Recombinant Murine BRAK (CXCL14) is a 9.4 kDa protein containing 77 amino acid residues.

Recombinant Murine BRAK (CXCL14) (Legacy Tebubio ref. 167250-45). Breast and Kidney‐expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP‐2 alpha and beta. Recombinant Murine BRAK (CXCL14) is a 9.4 kDa protein containing 77 amino acid residues.

Recombinant Human TNF-alpha (Legacy Tebubio ref. 167300-01A). TNF-alpha is a pleiotropic pro-inflammatory cytokine secreted by various cells, including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands, and signals through two receptors, TNFR1 and TNFR2. TNF-alpha is cytotoxic to a wide variety of tumor cells, and is an essential factor in mediating the immune response against bacterial infections. TNF-alpha also plays a role in the induction of septic shock, autoimmune diseases, rheumatoid arthritis, inflammation, and diabetes. Human and murine TNF-alpha demonstrate significant cross-species reactivity. TNF-alpha exists in two forms; a type II transmembrane protein, and a mature soluble protein. The TNF-alpha transmembrane protein is proteolitically cleaved to yield a soluble, biologically active, 17 kDa TNF-alpha, which forms a non-covalently linked homotrimer in solution. Recombinant Human TNF-alpha is a soluble 1

Recombinant Human TNF-alpha (Legacy Tebubio ref. 167300-01A). TNF-alpha is a pleiotropic pro-inflammatory cytokine secreted by various cells, including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands, and signals through two receptors, TNFR1 and TNFR2. TNF-alpha is cytotoxic to a wide variety of tumor cells, and is an essential factor in mediating the immune response against bacterial infections. TNF-alpha also plays a role in the induction of septic shock, autoimmune diseases, rheumatoid arthritis, inflammation, and diabetes. Human and murine TNF-alpha demonstrate significant cross-species reactivity. TNF-alpha exists in two forms; a type II transmembrane protein, and a mature soluble protein. The TNF-alpha transmembrane protein is proteolitically cleaved to yield a soluble, biologically active, 17 kDa TNF-alpha, which forms a non-covalently linked homotrimer in solution. Recombinant Human TNF-alpha is a soluble 1

Recombinant Human MCP-1 (CCL2) (Legacy Tebubio ref. 167300-04). The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Human MCP-1 is an 8.6 kDa protein containing 76 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines.

Recombinant Human MCP-1 (CCL2) (Legacy Tebubio ref. 167300-04). The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Human MCP-1 is an 8.6 kDa protein containing 76 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines.