Cytokines & Chemokines

Recombinant Human LD78beta (CCL3L1) (Legacy Tebubio ref. 167300-56). LD78beta is a CC chemokine that is closely related to MIP-1alpha. It signals through the CCR5 receptor and the beta-chemokine receptor, D6. LD78beta has been shown to exhibit potent activity in HIV suppression assays. Recombinant Human LD78beta is a 7.7 kDa protein containing 70 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

Recombinant Human MEC (CCL28) (Legacy Tebubio ref. 167300-57). MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor, and chemoattracts resting CD4, CD8T-cells and eosinophils. MEC contains six cysteines, including the four highly conserved cysteine residues present in CC chemokines. Recombinant Human MEC is a 12.3 kDa protein containing 108 amino acid residues.

Recombinant Human MEC (CCL28) (Legacy Tebubio ref. 167300-57). MEC is a secreted CC chemokine expressed primarily by epithelial cells of the bronchioles, salivary gland, mammary gland and colon. MEC signals through the CCR10 receptor, and chemoattracts resting CD4, CD8T-cells and eosinophils. MEC contains six cysteines, including the four highly conserved cysteine residues present in CC chemokines. Recombinant Human MEC is a 12.3 kDa protein containing 108 amino acid residues.

Recombinant Human LAG-1 (CCL4L1) (Legacy Tebubio ref. 167300-58). LAG-1 is CC chemokine that signals through the CCR5 receptor. LAG-1 is identical to MIP-1beta (ACT II isotype) except for two amino acid substitutions; arginine for histidine at position 22 and serine for glycine at position 47 of the mature protein. LAG-1 chemoattracts monocytes, and exhibits activity as an HIV-suppressive factor. Recombinant Human LAG-1 is a 7.7 kDa protein containing 69 amino acid residues.

Recombinant Human LAG-1 (CCL4L1) (Legacy Tebubio ref. 167300-58). LAG-1 is CC chemokine that signals through the CCR5 receptor. LAG-1 is identical to MIP-1beta (ACT II isotype) except for two amino acid substitutions; arginine for histidine at position 22 and serine for glycine at position 47 of the mature protein. LAG-1 chemoattracts monocytes, and exhibits activity as an HIV-suppressive factor. Recombinant Human LAG-1 is a 7.7 kDa protein containing 69 amino acid residues.

Recombinant Human TSLP (Legacy Tebubio ref. 167300-62). TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7, and binds with the heterodimeric receptor complex consisting of the IL-7R alpha-chain (IL-7Ralpha) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibits apoptosis and stimulates growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes, and activates CD11c(+) dendritic cells (DCs). TSLP-activated DCs have been shown to prime naive T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNF-alpha) while down-regulating IL-10 and IFN-gamma, suggesting a role in initiating allergic inflammation. Recombinant Human TSLP is a 15.0 kDa protein consisting of 132 amino acid residues.

Recombinant Human TSLP (Legacy Tebubio ref. 167300-62). TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7, and binds with the heterodimeric receptor complex consisting of the IL-7R alpha-chain (IL-7Ralpha) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibits apoptosis and stimulates growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes, and activates CD11c(+) dendritic cells (DCs). TSLP-activated DCs have been shown to prime naive T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNF-alpha) while down-regulating IL-10 and IFN-gamma, suggesting a role in initiating allergic inflammation. Recombinant Human TSLP is a 15.0 kDa protein consisting of 132 amino acid residues.

Recombinant Human TAFA-2 (Legacy Tebubio ref. 167300-63). TAFA proteins are a newly discovered family of proteins, which are distantly related to MIP-1alpha, a member of the CC-chemokine family. TAFA mRNAs are highly expressed in specific brain regions. The biological function of TAFA-2 is still unknown. Recombinant Human TAFA-2 is an 11.2 kDa protein consisting of 101 amino acid residues.

Recombinant Human TAFA-2 (Legacy Tebubio ref. 167300-63). TAFA proteins are a newly discovered family of proteins, which are distantly related to MIP-1alpha, a member of the CC-chemokine family. TAFA mRNAs are highly expressed in specific brain regions. The biological function of TAFA-2 is still unknown. Recombinant Human TAFA-2 is an 11.2 kDa protein consisting of 101 amino acid residues.