Results for Cytokines & Chemokines ( 2161 )
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Recombinant Human Resistin (Legacy Tebubio ref. 167450-19). Resistin belongs to a family of tissue-specific cytokines termed FIZZ (found in inflammatory zones) and RELM. The four known members of this family, resistin, RELMalpha, RELMbeta, and RELMgamma, share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Resistin is an adipose-derived cytokine (adipokine) whose physiological function and molecular targets are largely unknown. Studies have shown that resistin suppresses insulin's ability to stimulate glucose uptake, and postulated that resistin might be an important link between obesity and Type 2 diabetes. Other studies have indicated that resistin expression is severely suppressed in obesity, and that it may act as a feedback regulator of Adipogenesis. Recombinant Human Resistin is a 19.5 kDa, disulfide-linked, homodimeric protein composed of two identical 92 amino acid chains lin
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Recombinant Human RELMbeta (Legacy Tebubio ref. 167450-22). RELMbeta (Resistin-like molecule beta/FIZZ2) is a disulfide-linked, homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELMbeta, and its molecular targets, are not fully known, but it has been suggested that it plays a regulatory role during inflammation, and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly, the molecular structure of RELMbeta is highly homologous to that of the adipose-derived cytokines, resistin and RELMalpha. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Human RELMbeta is a 19.0 kDa protein, consisting of two identical 89 amino acid polypeptide chains linked by a single disulfide bond.
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Recombinant Human RELMbeta (Legacy Tebubio ref. 167450-22). RELMbeta (Resistin-like molecule beta/FIZZ2) is a disulfide-linked, homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELMbeta, and its molecular targets, are not fully known, but it has been suggested that it plays a regulatory role during inflammation, and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly, the molecular structure of RELMbeta is highly homologous to that of the adipose-derived cytokines, resistin and RELMalpha. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Human RELMbeta is a 19.0 kDa protein, consisting of two identical 89 amino acid polypeptide chains linked by a single disulfide bond.
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Recombinant Murine RELMalpha (Legacy Tebubio ref. 167450-26). RELMalpha belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The four known members of this family, resistin, RELMalpha, RELMbeta, and RELMgamma, are 85-94 amino acid, secreted proteins sharing a conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. RELMalpha and resistin are secreted exclusively by adipocytes, while RELMbeta is expressed in the epithelium of the colon and small bowel. The physiological role and molecular targets of RELMalpha are still unknown. Recombinant Murine RELMalpha is a 10.0 kDa monomeric protein containing 89 amino acid residues.
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Recombinant Murine RELMalpha (Legacy Tebubio ref. 167450-26). RELMalpha belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The four known members of this family, resistin, RELMalpha, RELMbeta, and RELMgamma, are 85-94 amino acid, secreted proteins sharing a conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. RELMalpha and resistin are secreted exclusively by adipocytes, while RELMbeta is expressed in the epithelium of the colon and small bowel. The physiological role and molecular targets of RELMalpha are still unknown. Recombinant Murine RELMalpha is a 10.0 kDa monomeric protein containing 89 amino acid residues.
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Recombinant Murine RELMbeta (Legacy Tebubio ref. 167450-26B). RELMbeta (Resistin-like molecule beta/FIZZ2) is a disulfide-linked, homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELMbeta, and its molecular targets, are not fully known, but it has been suggested that it plays a regulatory role during inflammation, and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly, the molecular structure of RELMbeta is highly homologous to that of the adipose-derived cytokines, resistin and RELMalpha. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Murine RELMbeta is an 18.0 kDa protein, consisting of two identical 83 amino acid polypeptide chains linked by a single disulfide bond.
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Recombinant Murine RELMbeta (Legacy Tebubio ref. 167450-26B). RELMbeta (Resistin-like molecule beta/FIZZ2) is a disulfide-linked, homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELMbeta, and its molecular targets, are not fully known, but it has been suggested that it plays a regulatory role during inflammation, and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly, the molecular structure of RELMbeta is highly homologous to that of the adipose-derived cytokines, resistin and RELMalpha. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Murine RELMbeta is an 18.0 kDa protein, consisting of two identical 83 amino acid polypeptide chains linked by a single disulfide bond.
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Recombinant Murine RELMgamma (Legacy Tebubio ref. 167450-26G). RELMgamma belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The other three known members of this family, resistin, RELMalpha, and RELMbeta, are 85-94 amino acid, secreted proteins sharing a conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. RELMgamma is most closely related to RELMalpha, but is distinctly secreted in the bone marrow, spleen, lung, and peripheral blood granulocytes. The physiological role of RELMgamma may include the promotion or regulation of promyelocytic differentiation, although the specific molecular targets of RELMgamma have not been identified. Recombinant Murine RELMgamma is a 9.2 kDa monomeric protein containing 88 amino acid residues.
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Recombinant Murine RELMgamma (Legacy Tebubio ref. 167450-26G). RELMgamma belongs to a unique family of tissue-specific cytokines termed FIZZ (found in inflammatory zone) and RELM. The other three known members of this family, resistin, RELMalpha, and RELMbeta, are 85-94 amino acid, secreted proteins sharing a conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. RELMgamma is most closely related to RELMalpha, but is distinctly secreted in the bone marrow, spleen, lung, and peripheral blood granulocytes. The physiological role of RELMgamma may include the promotion or regulation of promyelocytic differentiation, although the specific molecular targets of RELMgamma have not been identified. Recombinant Murine RELMgamma is a 9.2 kDa monomeric protein containing 88 amino acid residues.