Cytokines & Chemokines

Animal-Free Recombinant Human Leptin (Legacy Tebubio ref. 167AF-300-27). Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Human Leptin is a 16.0 kDa protein containing 147 amino acid residues.

Animal-Free Recombinant Human Leptin (Legacy Tebubio ref. 167AF-300-27). Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant Human Leptin is a 16.0 kDa protein containing 147 amino acid residues.

Animal-Free Recombinant Human SDF-1alpha (CXCL12) (Legacy Tebubio ref. 167AF-300-28A). SDF-1alpha and beta are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1alpha and beta chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1alpha and beta contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1alpha protein is the result of alternative splicing of the SDF-1 gene and contains 68 amino acid residues. Recombinant Human SDF-1alpha is an 8.0 kDa protein containing 68 amino acid residues.

Animal-Free Recombinant Human SDF-1alpha (CXCL12) (Legacy Tebubio ref. 167AF-300-28A). SDF-1alpha and beta are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1alpha and beta chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1alpha and beta contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1alpha protein is the result of alternative splicing of the SDF-1 gene and contains 68 amino acid residues. Recombinant Human SDF-1alpha is an 8.0 kDa protein containing 68 amino acid residues.

Animal-Free Recombinant Human SDF-1beta (CXCL12) (Legacy Tebubio ref. 167AF-300-28B). SDF-1alpha and beta are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1alpha and beta chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1alpha and beta contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1beta protein, produced by an N-terminal truncation of two additional amino acids, after removal of the signal sequence, contains 72 amino acid residues. Recombinant Human SDF-1beta is an 8.5 kDa protein containing 72 amino acid residues.

Animal-Free Recombinant Human SDF-1beta (CXCL12) (Legacy Tebubio ref. 167AF-300-28B). SDF-1alpha and beta are stromal-derived, CXC chemokines that signal through the CXCR4 receptor. SDF-1alpha and beta chemoattract B and T cells, and have been shown to induce migration of CD34+ stem cells. Additionally, the SDF-1 proteins exert HIV-suppressive activity in cells expressing the CXCR4 receptor. Human and murine SDF-1 proteins act across species. SDF-1alpha and beta contain the four highly conserved cysteine residues present in CXC chemokines. The mature SDF-1beta protein, produced by an N-terminal truncation of two additional amino acids, after removal of the signal sequence, contains 72 amino acid residues. Recombinant Human SDF-1beta is an 8.5 kDa protein containing 72 amino acid residues.

Animal-Free Recombinant Human TECK (CCL25) (Legacy Tebubio ref. 167AF-300-45). TECK is a CC chemokine, specifically expressed by thymic stromal cells, and signals through the CCR9 receptor. TECK is chemotactic towards activated macrophages, thymocytes and dendritic cells. Recombinant Human TECK (CCL25) is a 14.2 kDa protein containing 127 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

Animal-Free Recombinant Human TECK (CCL25) (Legacy Tebubio ref. 167AF-300-45). TECK is a CC chemokine, specifically expressed by thymic stromal cells, and signals through the CCR9 receptor. TECK is chemotactic towards activated macrophages, thymocytes and dendritic cells. Recombinant Human TECK (CCL25) is a 14.2 kDa protein containing 127 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

Animal-Free Recombinant Human I-TAC (CXCL11) (Legacy Tebubio ref. 167AF-300-46). I-TAC is a 'non-ELR' CXC chemokine that is regulated by interferon and signals through the CXCR3 receptor. I-TAC is chemoattractant for IL-2 activated T cells, but does not affect freshly isolated un-stimulated T cells, neutrophils, ormonocytes. Recombinant Human I-TAC (CXCL11) is an 8.3 kDa protein containing 73 amino acid residues, including the four highly conserved cysteine residues present in CXC chemokines.