Cytokines & Chemokines

Recombinant Murine IL-17A (Legacy Tebubio ref. 167210-17). The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains that are secreted by activated T-cells, which act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant Murine IL-17A is a 30.0 kDa, disulfide-linked homodimer of two 133 amino acid, polypeptide chains.

Recombinant Murine IL-17D (Legacy Tebubio ref. 167210-17D). IL‐17D is a disulfide‐linked homodimer of two 185 amino acid polypeptide chains. It belongs to the IL‐17 family of structurally‐related cytokines that share a highly conserved C‐terminal region, but differ from one another in their N‐terminal regions and in their distinct biological roles. The six known members of this family, IL‐17A through IL‐17F, are secreted as homodimers. IL‐17D has the ability to stimulate the production of IL‐6, IL‐8 and GM‐CSF, and inhibits hemopoiesis of myeloid progenitor cells in colony‐forming assays. Recombinant Murine IL-17D is a 40.6 kDa, disulfide-linked homodimer of two 183 amino acid, polypeptide chains.

Recombinant Murine IL-17D (Legacy Tebubio ref. 167210-17D). IL‐17D is a disulfide‐linked homodimer of two 185 amino acid polypeptide chains. It belongs to the IL‐17 family of structurally‐related cytokines that share a highly conserved C‐terminal region, but differ from one another in their N‐terminal regions and in their distinct biological roles. The six known members of this family, IL‐17A through IL‐17F, are secreted as homodimers. IL‐17D has the ability to stimulate the production of IL‐6, IL‐8 and GM‐CSF, and inhibits hemopoiesis of myeloid progenitor cells in colony‐forming assays. Recombinant Murine IL-17D is a 40.6 kDa, disulfide-linked homodimer of two 183 amino acid, polypeptide chains.

Recombinant Murine IL-17E (Legacy Tebubio ref. 167210-17E). IL‐17E is a disulfide‐linked homodimer of two 145 amino acid polypeptide chains. It belongs to the IL‐17 family of structurally‐related cytokines that share a highly conserved C‐terminal region, but differ from one another in their N‐terminal regions and in their distinct biological roles. The six known members of this family, IL‐17A through IL‐17F, are secreted as homodimers. IL‐17E stimulates secretion of IL‐8, and induces activation of the transcription factor NF‐κB in cells that express the IL‐17BR receptor. Recombinant Murine IL‐17E is a 35.0 kDa disulfide‐linked homodimer of two 152-amino-acid polypeptide chains.

Recombinant Murine IL-17E (Legacy Tebubio ref. 167210-17E). IL‐17E is a disulfide‐linked homodimer of two 145 amino acid polypeptide chains. It belongs to the IL‐17 family of structurally‐related cytokines that share a highly conserved C‐terminal region, but differ from one another in their N‐terminal regions and in their distinct biological roles. The six known members of this family, IL‐17A through IL‐17F, are secreted as homodimers. IL‐17E stimulates secretion of IL‐8, and induces activation of the transcription factor NF‐κB in cells that express the IL‐17BR receptor. Recombinant Murine IL‐17E is a 35.0 kDa disulfide‐linked homodimer of two 152-amino-acid polypeptide chains.

Recombinant Murine IL-17F (Legacy Tebubio ref. 167210-17F). IL-17F, a member of the IL-17 family of structurally related cytokines, has been shown to stimulate proliferation and activation of T cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis. Recombinant Murine IL-17F is a 30.0 kDa, disulfide-linked homodimer consisting of two 134 amino acid residue chains.

Recombinant Murine IL-17F (Legacy Tebubio ref. 167210-17F). IL-17F, a member of the IL-17 family of structurally related cytokines, has been shown to stimulate proliferation and activation of T cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis. Recombinant Murine IL-17F is a 30.0 kDa, disulfide-linked homodimer consisting of two 134 amino acid residue chains.

Recombinant Murine IL-21 (Legacy Tebubio ref. 167210-21). IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include: inducing the differentiation of T cell-stimulated B cells into plasma cells and memory B cells; the stimulation of IgG production in conjunction with IL-4; and the induction of apoptotic effects in naive B cells and stimulated B cells in the absence of T cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (gammac) found in other cytokine receptors, including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcriptio

Recombinant Murine IL-21 (Legacy Tebubio ref. 167210-21). IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include: inducing the differentiation of T cell-stimulated B cells into plasma cells and memory B cells; the stimulation of IgG production in conjunction with IL-4; and the induction of apoptotic effects in naive B cells and stimulated B cells in the absence of T cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the gamma chain (gammac) found in other cytokine receptors, including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcriptio