Peptides & Amino Acids

APYTFGQGTK peptide is a sequence from light chain of Adalimumab monoclonal antibody. Due to its universal location in Adalimumab antibody, Stable Isotope Labeled (SIL) APYTFGQGTK is used as a specific signature peptide for the quantitation of Adalimumab. Indeed, proteomic studies allows quantification of proteins in blood samples. By this way, APYTFGQGTK peptide can be isotope labeled and used as an internal standard for Liquid Chromatography/ Mass Spectrometry (LC/MS) analysis. Using 13C and 15N-labeled Lysine, the heavy Adalimumab peptide sequence will have an increased mass but will keep the same properties. With a high sensitive and specific level, bioanalytical studies with stable isotope labeled signature peptides corresponds to the gold standard for accurate targeted quantitative proteomics. What is Adalimumab? Adalimumab corresponds to a therapeutic monoclonal antibody. It is a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthrit

Spike (S) glycoprotein corresponds to one of the leading targets for COVID-19 disease. Present on the surface of Sars-CoV-2 virus, Spike S protein is a class I fusion protein that allows the virus to enter host cells. With a 1 273 aa length, Spike protein has 2 subunits : S1 contains the receptor-binding domain RBD and S2 induces the fusion of the viral envelop with the cellular membrane. The S1 subunit allows binding to the Angiotensin-Converting Enzyme receptor 2 (ACE2 receptor) which mediates the viral entry. Spike (S) is a glycoprotein of 1 273 aa length. sb-PEPTIDE offers a library made of 316 peptides with a length of 15 amino acids and an overlap of 11 amino acids without post-translational modificaton.

Biotinylated version of the Spike (S) glycoprotein which corresponds to one of the leading targets for COVID-19 disease. Present on the surface of Sars-CoV-2 virus, Spike S protein is a class I fusion protein that allows the virus to enter host cells. With a 1 273 aa length, Spike protein has 2 subunits : S1 contains the receptor-binding domain RBD and S2 induces the fusion of the viral envelop with the cellular membrane. The S1 subunit allows binding to the Angiotensin-Converting Enzyme receptor 2 (ACE2 receptor) which mediates the viral entry. Spike (S) is a glycoprotein of 1 273 aa length. sb-PEPTIDE offers a library made of 316 biotinylated-peptides with a length of 15 amino acids and an overlap of 11 amino acids without post-translational modificaton.

The Nucleocapsid Protein (N-protein), also called coronavirus nucleocapsid (N), is the most abundant protein in coronavirus. It is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly. N-protein is a highly immunogenic phosphoprotein, and it is normally very conserved. It contains 419 amino acids in length. Coronavirus Nucleocapsid (N) is a phosphoprotein of 419 aa length. sb-PEPTIDE offers a library of 102 peptides with a length of 15 amino acids and an overlap of 11 amino acids (without post-translational modification).

3x DYKDDDDK peptide, also called 3x FLAG peptide, is a 23 aa length peptide used for the competitive elution of DYKDDDDK-tag fusion proteins (with excess of free 3x DYKDDDDK peptide) under non-denaturing conditions, especially when a DYKDDDDK-tagged protein is sensitive to low pH. Involvement in COVID-19 disease Some recombinant proteins, such as Spike glycoprotein and ACE2 are frequently produced using the FLAG-tag system. In order to elute such proteins purified by affinity, sb-PEPTIDE provides DYKDDDDK peptide and 3x DYKDDDDK peptide. To help your research for COVID-19 disease, we can also provide you with premium quality peptide libraries containing SARS-CoV-2 proteins. Our expertise make us able to synthesize glycopeptides and phosphopeptides to be close from the real content of these peptides. For more information, please visit this link

DYKDDDDK-peptide is a 8 aa length peptide used for the competitive elution of FLAG fusion proteins (with excess of free DYKDDDDK-peptide) under non-denaturing conditions. Involvement in COVID-19 disease Some recombinant proteins, such as Spike glycoprotein and ACE2 are frequently produced using the DYKDDDDK-tag system. In order to purify or detect that proteins, sb-PEPTIDE provides DYKDDDDK-peptide and 3x DYKDDDDK–peptide. To help your research for COVID-19 disease, we can also provide you with premium quality peptide libraries containing SARS-CoV-2 proteins. Our expertise make us able to synthesize glycopeptides and phosphopeptides to be close from the real content of these peptides. For more information, please visit this link.

Angiotensin-converting enzyme 2 (ACE2) is an enzyme involved in the cardiovascular system by decreasing arterial pressure by catalyzing the conversion of angiotensin II to angiotensin (1-7). Angiotensin II is a vasoconstrictor and angiotensin (1-7) is a vasodilatator. This effect makes ACE2 a therapeutic target for cardiovascular disease. Otherwise, ACE2 also corresponds to a receptor allowing the coronavirus (SARS-CoV-2) to enter the host cell. sb-PEPTIDE provides ACE2 as an overlaped library with peptides of 15 amino acids with an overlap of 11 amino acids. 1 peptide per well.

Heavy calcitonin peptide – Stable Isotope PeptideHuman Calcitonin (hCT) is a 32-amino acid hormone peptide belonging to the Calcitonin/Calcitonin-gene related peptide (CGRP) family, that also comprises amylin, adrenomedullin (AM) and adrenomedullin2/intermedin (AM2/IMD). Calcitonin is characterized by a N-terminal disulfide bond that forms a 7 amino acid ring structure, a region with a α-helix tendency and an amidated C-terminus1.Calcitonin peptide is produced by C cells of the thyroid gland and binds preferentially to the G-protein coupled receptor, calcitonin receptor (CTR)1. Calcitonin receptor signals through activated Gs protein and the production of cAMP second messenger molecules by adenylyl cyclase1. The dissociation constant (Kd) of calcitonin receptors expressed by a human ovarian small cell carcinoma line is approximately 4.6 nM for human Calcitonin2.Calcitonin is involved in the homeostasis of calcium and phosphorus, and the regulation of bone dynamics. At the basal state,

MiniAP-4 peptide is a short nontoxic derivative of apamin (a neurotoxin from bee venom) used as a blood-brain barrier (BBB) shuttle peptide. The blood brain barrier has been known as the major barrier for drug delivery to the brain. Therefore, BBB shuttle peptides can be used to bind therapeutic molecules to allow their distribution in the central nervous system (CNS). BBB shuttle peptides are a good way to enable central nervous system therapies because these molecules are more economical, less immunogenic, and have higher chemical versatility than large proteins. On the other hand, they are often metabolized by serum proteases.To overcome this problem, some peptides found in venoms can target the CNS directly, such as apamin, which has been modified to form MiniAp-4 (a non-toxic and non-immunogenic apamin derivative) which stands out as the vector of choice. Indeed, this carrier, MiniAp-4 peptide, is protease-resistant and has negligible toxicity and immunogenicity.