Peptides & Amino Acids

Neuropeptide: Neuropeptides are small signaling molecules produced and released by neurons engaged in many physiological functions. Indeed, neuropeptides act on neural substrates such as G protein-coupled receptors (GPCRs), tyrosine-kinase receptor, insuline-like peptides and also ion channels. Actions of Neuropeptides result in slow-onset, long-lasting modulation of synaptic transmission. Pro-FMRFamide-related neuropeptide VF: Pro-FMRFamide-related neuropeptide VF also called neuropeptide VF precursor are expressed in neurons in mediobasal hypothalamus. Neuropeptide VF precursor is a propeptide which is cleaved in three others peptide: Neuropeptide RFRP-1, RFRP-2 and RFRP-3. Neuropeptide RFRP-3 (124-131): Neuropeptide RFRP-3 acts as a potent synthesis and secretion gonadotropin inhibitor. Neuropeptide RFRP-3 inhibit forskolin-induced production of cAMP and progesterone production in human cells. Neuropeptide RFRP-3 (124-131) is a part of RFRP-3 and is useful in opioid research.

Neuropeptide: Neuropeptides are small signaling molecules produced and released by neurons engaged in many physiological functions. Indeed, neuropeptides act on neural substrates such as G protein-coupled receptors (GPCRs), tyrosine-kinase receptor, insuline-like peptides and also ion channels. Actions of Neuropeptides result in slow-onset, long-lasting modulation of synaptic transmission. Pro-FMRFamide-related neuropeptide VF: Pro-FMRFamide-related neuropeptide VF also called neuropeptide VF precursor are expressed in neurons in mediobasal hypothalamus. Neuropeptide VF precursor is a propeptide which is cleaved in three others peptide: Neuropeptide RFRP-1, RFRP-2 and RFRP-3. Neuropeptide RFRP-2 (101-112): Neuropeptide RFRP-2 (101-112) is very interesting because RFRP-2 shows no inhibitory activity and RFRP-2 sequence is absent in mouse and rat.

Myelin Basic Protein (MBP) MBP-B (84-102) DRB1*15:01 is a short part of the myelin basic peptide. Myelin basic protein is one of the major protein found in myelin. MBP-B (84-102) DRB1*15:01 MBP-B (84-102) DRB1*15:01 is used to stimulate immune response and T cell activity. MBP-B (84-102) DRB1*15:01 is also considered as a reference positive control in binding affinity with DRB1*15:01 molecules.

Myoglobin Myoglobin 137-148 MHC II DRB1*03:01 is a short part of Myoglobin. Myoglobin is protein which binds oxygen or also iron in the skeletal muscle tissue. Myoglobin 137-148 MHC II DRB1*03:01 Myoglobin 137-148 MHC II DRB1*03:01 is a classical peptide reference for the binding avec MHC II DRB1*03:01. Myoglobin 137-148 is often used to be in competition for study of the relative binding affinity.

Influenza virus-specific hemagglutinin Flu-HA-B (306-318) is a short part of Influenza hemagglutinin (HA). Influenza hemagglutinin is glycoprotein found on the surface of influenza viruses. HA allows Influenza virus to bind factor on the surface of the cell membrane. HA is also responsible for the membrane fusion with the viral envelope. Flu-HA-B (306-318) DRB1*01:01 Flu-HA-B (306-318) is a classical antigenic peptide which is used as positive control to bind DRB1*01:01 for peptide/MHC-binding assay. It has been demonstrated the ability of HLA-DRB1*01:01 to present Flu-HA-B (306-318).

Tetanus toxin TetTox-B (830-843) DRB1*07:01 is a short part of the tetanus toxin. Tetanus toxin is produced by Clostridium tetani and is a potent neurotoxin. Indeed, tetanus toxin arrives on bloodstream and moves to a receptor complex at the neuromuscular junction. TetTox-B (830-843) DRB1*07:01 TetTox-B (830-843) DRB1*07:01 is used to stimulate the immune response and to generate DRB1*07:01-restricted T cells specific for the tetanus toxin peptide. TetTox-B (830-843) is also a classical peptide reference for the binding affinity with DRB1*07:01 molecules.

CMV pp65 is a pool of peptides which covers the complete sequence of the pp65 protein of human cytomegalovirus. It induces in vitro stimulation of antigen-specific CD4 and CD8 T cells.

Spike S peptide is a peptide pool made of 15-mer peptides with 11–amino acid (aa) overlap, covering the complete sequence of the Spike S protein.

PACAP 1-27 (Pituitary adenylate cyclase-activating polypeptide 27) is a potent stimulator of adenylyl cyclase and increases cAMP levels.