Peptides & Amino Acids

MBP (Myelin Basic Protein – UniProtKB – P04370) is a major constituent of the myelin in nerves. This protein permits the maintain of the myelin structure. MBP contains various epitopes implicated in Multiple Sclerosis. MBP (84-97) induces EAE The MBP 84-97 peptide is an immunodominant epitope of MBP. The sequence is conserved in various species (guinea pig, human…). MBP84-97 is used to induce EAE (Experimental Autoimmune Encephalomyelitis).

MOG (183-191) FVIVPVLGP MOG (Mouse Myelin Oligodendrocyte Glycoprotein – UniProtKB – Q61885) is a minor component of the myelin sheath of the CNS (Central Nervous System). This protein plays a role in the maintenance of the myelin sheath and in cell-cell communication. MOG (Myelin oligodendrocyte glycoprotein) is an integral membrane glycoprotein type I of the immunoglobulin family (Ig) found exclusively in mammals with a molecular weight around 26-28 kDa. MOG 183-191 induces EAE Multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS), is characterized by primary demyelination. EAE (experimental autoimmune encephalomyelitis) is the most commonly used experimental model for studying multiple Sclerosis. The MOG (183-191) peptide can be used to induce an immune response and provoke a demyelination of the CNS (Central Nervous System). MOG183-191 can generate specific anti-MOG 183-191 antibodies. This process leads to an experimental autoimmune encephalomyelitis

Biotin-Ova (323-339) is the N-ter biotinylated version of Ova (323-339). Biotin-Ova (323-339) can be used in the analysis of antigen-specific T cells. Ovalbumin protein: Ova (323-339) is an epitope of interest of the egg white albumen, which is widely used in allergy research. Ovalbumin is a glycoprotein that is sufficiently large and complex to be mildly immunogenic. Indeed, it has been demonstrated that Ovalbumin contains B-cell epitopes which are recognized by specific IgE antibodies and CD4 T cell epitopes restricted by the MHC I-Ad molecule in mice and by HLA-D molecule in human. Applications of Ova (323-339): Ova (323-339) allows to study bindings of class II MHC-peptide and T-cell activation in PBMCs by ELISPOT assays. In fact, this method quantifies peptide epitope specificity and IFN-γ releasing effector cells. It has been shown that Ova (323-339) was responsible for 25-35% of T-cell response of isolated BALB/c mouse. An investigation has demonstrated that Ova and Ova (323-33

IGF-1, insulin-like growth factor, also called as somatomedin 1, is a hormone peptide similar in structure to insulin. IGF-1 is released in the presence of growth hormone and mediates its enterotrophic effect.

Adropin is a secreted hormone that regulates lipid and glucose metabolism. It is mainly expressed in brain and liver and is encoded by the energy homeostasis associated gene. It has been shown that adropin has beneficial effect in obesity animal models.

Xenin (Xenin-25) is a peptide hormone that was originally isolated from intestinal mucosa. Xenin is produced through pepsin cleavage of the 35-amino acids long pro-xenin. Xenin is involved in appetite suppression, GIP potentiation, and lipid metabolism.

Preptin is a 34 amino acid peptide hormone that is produced from Asp(69)-Leu(102) of pro-IGF-II and is secreted by pancreatic β-cells. Preptin has been located in mammary tissue, the pancreas, and kidneys. High plasma concentrations of preptin was associated with obesity.

Pancreastatin (24-52) or hPST29 peptide is one of the active short variants of the full-length peptide. It inhibits production of glycogen and regulates glucose-induced insulin secretion, lipid and protein metabolism in adipose tissue and liver.

Pancreastatin peptide is produced by proteolytic cleavage from Chromatogranin A. PSTi8 or pancreastatin (24-44) peptide is one of the active short variants of the full-length peptide. It inhibits production of glycogen and regulates glucose-induced insulin secretion, lipid and protein metabolism in adipose tissue and liver. PSTi8 was found to have potent antidiabetic activity in animal models.