Peptides & Amino Acids

GIP (Glucose-dependent Insulinotropic Polypeptide or also known as Gastric Inhibitory Polypeptide) is a 42-amino acid peptide released by the K cells of the duodenum and jejunum in response to food intake. GIP (6-30) is a short active version of the 42-amino acid long peptide. Together with GLP (Gastric-like Peptide) these peptides are members of the hormone peptide family of incretins which stimulate insulin secretion from pancreatic islet β-cells, and also appears to promote beta cell proliferation and beta cell survival. Recent studies suggest that GIP plays a role in lipid homeostasis and possibly in the pathogenesis of obesity.

GIP (Glucose-dependent Insulinotropic Polypeptide or also known as Gastric Inhibitory Polypeptide) is a 42-amino acid peptide released by the K cells of the duodenum and jejunum in response to food intake. GIP, together with GLP (Gastric-like Peptide) are members of the hormone peptide family of Incretins which stimulate insulin secretion from pancreatic islet β-cells, and also appears to promote beta cell proliferation and beta cell survival. Recent studies suggest that GIP plays a role in lipid homeostasis and possibly in the pathogenesis of obesity.

Glucagon is a peptide hormone secreted from the pancreatic Islet of Langerhans alpha-cells, in response to low circulating blood glucose levels in order to restore normal glucose levels. It acts on hepatic enzymes that regulate glucose production and glycogen synthesis. Excessive amounts of circulating glucagon levels is implicated in the metabolic dysregulation of type 2 diabetes, since such conditions result in hyperglycaemia.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the COVID-19 pandemic. Widespread of COVID-19 has sparked search for SARS inhibitors that target the virus-host cell interaction and virus replication itself. This SARS-inhibitor 1 affects enzyme activity of the virus 2-O-methyltransferase.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the COVID-19 pandemic. Widespread infectivity of COVID-19 has sparked the search for SARS inhibitors that target the virus-host cell interaction and virus replication itself. This SARS-inhibitor 2 inhibits binding of the virus to the host cell membrane.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the COVID-19 pandemic. Widespread infectivity of COVID-19 has sparked the search for SARS inhibitors that target the virus-host cell interaction and virus replication itself. This SARS-inhibitor 3 inhibits the SARS-COVID2019 spike protein from binding to the ACE2 enzyme that serves as a receptor for the virus.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the COVID-19 pandemic. Widespread infectivity of COVID-19 has sparked the search for SARS inhibitors that target the virus-host cell interaction and virus replication itself. This SARS-inhibitor 4 inhibits the SARS-COVID2019 spike protein from binding to the ACE2 enzyme that serves as a receptor for the virus.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the COVID-19 pandemic. Widespread infectivity of COVID-19 has sparked the search for SARS inhibitors that target the virus-host cell interaction and virus replication itself. Some antimicrobial peptides such as defensins possess antiviral properties. This SARS-inhibitor 5, alpha defensin peptide, inhibits SARS-COVID spike protein from binding to the ACE2 enzyme that serves as a receptor for the virus.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of the COVID-19 pandemic. Widespread infectivity of COVID-19 has sparked the search for SARS inhibitors that target the virus-host cell interaction and virus replication itself. This Spike protein SARS-CoV-2 sensitive substrate is specific for the spike protein and mimics the furin cleavage site of human epithelial sodium channel. Thus it can be used for screening of SARS-COVID2019 inhibitors.