Peptides & Amino Acids

KLPGF peptide is a sequence from egg white albumen. This peptide have recently shown interest for Alzheimer’s disease. Involvement in Alzheimer’s disease This peptide fragment, KLPGF, demonstrated recently an activity against Acetylcholinesterase (AchE), which is implicated in Alzheimer’s diseases and corresponds to the target of almost all Alzheimer’s disease treatmets. Actually, a deficiency in the brain levels of acetylcholine is seen as key step in the pathogenesis of Alzheimer disease. Otherwise, KLPGF peptide seems to inhibit the activity of Butyrylcholinesterase (BchE) and Beta-site APP cleaving enzyme 1 (BACE1), which is one of the most promising new therapeutic approaches for Alzheimer’s diseases. Indeed, this receptor induce the formation of Amyloid Beta, a typical peptide from Alzheimer’s diseases. In a recent study (Zhipeng Yu et al, Biological evaluation and interaction mechanism of beta-site APP cleaving enzyme 1 inhibitory pentapeptide from egg albumin, Food Science

Ovalbumin 154-159, also nammed TNGIIR peptide, is a portion of interest of the egg white albumen. Anti-hypertensive activity TNGIIR peptide has been described to have a protective activity on the blood pressure by inhibiting the Angiotensin-Converting Enzyme (ACE). The concentration of the peptide, necessary to inhibit 50% of the activity of ACE, was 70 μM. Involvement in Alzheimer’s disease Ovalbumin 154-159 peptide demonstrated recently an activity against Acetylcholinesterase (AchE), which is implicated in Alzheimer’s diseases. Actually, a deficiency in the brain levels of acetylcholine is seen as key step in the pathogenesis of Alzheimer disease. Otherwise, Ovalbumin 154-159 seems to be involved in a possible inhibition of beta-site APP clieaving enzyme 1 (BACE1), which is one of the most promising new therapeutic approaches for Alzheimer’s diseases. Indeed, this receptor induce the formation of Amyloid Beta, a typical peptide from Alzheimer’s diseases.

APYTFGQGTK peptide is a sequence from light chain of Adalimumab monoclonal antibody. Due to its universal location in Adalimumab antibody, Stable Isotope Labeled (SIL) APYTFGQGTK is used as a specific signature peptide for the quantitation of Adalimumab. Indeed, proteomic studies allows quantification of proteins in blood samples. By this way, APYTFGQGTK peptide can be isotope labeled and used as an internal standard for Liquid Chromatography/ Mass Spectrometry (LC/MS) analysis. Using 13C and 15N-labeled Lysine, the heavy Adalimumab peptide sequence will have an increased mass but will keep the same properties. With a high sensitive and specific level, bioanalytical studies with stable isotope labeled signature peptides corresponds to the gold standard for accurate targeted quantitative proteomics. What is Adalimumab? Adalimumab corresponds to a therapeutic monoclonal antibody. It is a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthrit

Spike (S) glycoprotein corresponds to one of the leading targets for COVID-19 disease. Present on the surface of Sars-CoV-2 virus, Spike S protein is a class I fusion protein that allows the virus to enter host cells. With a 1 273 aa length, Spike protein has 2 subunits : S1 contains the receptor-binding domain RBD and S2 induces the fusion of the viral envelop with the cellular membrane. The S1 subunit allows binding to the Angiotensin-Converting Enzyme receptor 2 (ACE2 receptor) which mediates the viral entry. Spike (S) is a glycoprotein of 1 273 aa length. sb-PEPTIDE offers a library made of 316 peptides with a length of 15 amino acids and an overlap of 11 amino acids without post-translational modificaton.

Biotinylated version of the Spike (S) glycoprotein which corresponds to one of the leading targets for COVID-19 disease. Present on the surface of Sars-CoV-2 virus, Spike S protein is a class I fusion protein that allows the virus to enter host cells. With a 1 273 aa length, Spike protein has 2 subunits : S1 contains the receptor-binding domain RBD and S2 induces the fusion of the viral envelop with the cellular membrane. The S1 subunit allows binding to the Angiotensin-Converting Enzyme receptor 2 (ACE2 receptor) which mediates the viral entry. Spike (S) is a glycoprotein of 1 273 aa length. sb-PEPTIDE offers a library made of 316 biotinylated-peptides with a length of 15 amino acids and an overlap of 11 amino acids without post-translational modificaton.

The Nucleocapsid Protein (N-protein), also called coronavirus nucleocapsid (N), is the most abundant protein in coronavirus. It is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly. N-protein is a highly immunogenic phosphoprotein, and it is normally very conserved. It contains 419 amino acids in length. Coronavirus Nucleocapsid (N) is a phosphoprotein of 419 aa length. sb-PEPTIDE offers a library of 102 peptides with a length of 15 amino acids and an overlap of 11 amino acids (without post-translational modification).

3x DYKDDDDK peptide, also called 3x FLAG peptide, is a 23 aa length peptide used for the competitive elution of DYKDDDDK-tag fusion proteins (with excess of free 3x DYKDDDDK peptide) under non-denaturing conditions, especially when a DYKDDDDK-tagged protein is sensitive to low pH. Involvement in COVID-19 disease Some recombinant proteins, such as Spike glycoprotein and ACE2 are frequently produced using the FLAG-tag system. In order to elute such proteins purified by affinity, sb-PEPTIDE provides DYKDDDDK peptide and 3x DYKDDDDK peptide. To help your research for COVID-19 disease, we can also provide you with premium quality peptide libraries containing SARS-CoV-2 proteins. Our expertise make us able to synthesize glycopeptides and phosphopeptides to be close from the real content of these peptides. For more information, please visit this link

DYKDDDDK-peptide is a 8 aa length peptide used for the competitive elution of FLAG fusion proteins (with excess of free DYKDDDDK-peptide) under non-denaturing conditions. Involvement in COVID-19 disease Some recombinant proteins, such as Spike glycoprotein and ACE2 are frequently produced using the DYKDDDDK-tag system. In order to purify or detect that proteins, sb-PEPTIDE provides DYKDDDDK-peptide and 3x DYKDDDDK–peptide. To help your research for COVID-19 disease, we can also provide you with premium quality peptide libraries containing SARS-CoV-2 proteins. Our expertise make us able to synthesize glycopeptides and phosphopeptides to be close from the real content of these peptides. For more information, please visit this link.

Angiotensin-converting enzyme 2 (ACE2) is an enzyme involved in the cardiovascular system by decreasing arterial pressure by catalyzing the conversion of angiotensin II to angiotensin (1-7). Angiotensin II is a vasoconstrictor and angiotensin (1-7) is a vasodilatator. This effect makes ACE2 a therapeutic target for cardiovascular disease. Otherwise, ACE2 also corresponds to a receptor allowing the coronavirus (SARS-CoV-2) to enter the host cell. sb-PEPTIDE provides ACE2 as an overlaped library with peptides of 15 amino acids with an overlap of 11 amino acids. 1 peptide per well.