Peptides & Amino Acids

N3-H8 is a clickable CPP.

Apolipoprotein E fragment (133-149) – COG133: acetyl-LRVRLASHLRKLRKRLL-NH2 (CAS : 514200-66-9) SB-PEPTIDE offers Apolipoprotein E (ApoE) mimetic peptide COG133 – LRVRLASHLRKLRKRLL – which competes with the ApoE holoprotein for binding the low density lipoprotein (LDL) receptor. Apolipoprotein E (ApoE): A key player in lipid transport and beyond Apolipoprotein E (apoE) is a low-density lipoprotein (LDL) receptor ligand that belongs to the family of fat-binding proteins, known as apolipoproteins. While the liver and macrophages primarily produce ApoE in peripheral tissues to mediate cholesterol metabolism, in the central nervous system (CNS), astrocytes take the lead in producing ApoE. ApoE plays a vital role in lipid transport, facilitating the movement of lipids such as fats, cholesterol, and fat-soluble vitamins between organs via plasma and interstitial fluids. In the central CNS, it serves as a crucial cholesterol carrier, promoting neuron survival, sprouting, and exhibiting

MBP (Myelin Basic Protein – UniProtKB – P04370) is a major constituent of the myelin in nerves. This protein permits the maintain of the myelin structure. MBP contains various epitopes implicated in Multiple Sclerosis. MBP (84-97) induces EAE The MBP 84-97 peptide is an immunodominant epitope of MBP. The sequence is conserved in various species (guinea pig, human…). MBP84-97 is used to induce EAE (Experimental Autoimmune Encephalomyelitis).

MOG (183-191) FVIVPVLGP MOG (Mouse Myelin Oligodendrocyte Glycoprotein – UniProtKB – Q61885) is a minor component of the myelin sheath of the CNS (Central Nervous System). This protein plays a role in the maintenance of the myelin sheath and in cell-cell communication. MOG (Myelin oligodendrocyte glycoprotein) is an integral membrane glycoprotein type I of the immunoglobulin family (Ig) found exclusively in mammals with a molecular weight around 26-28 kDa. MOG 183-191 induces EAE Multiple sclerosis (MS), an autoimmune disease of the central nervous system (CNS), is characterized by primary demyelination. EAE (experimental autoimmune encephalomyelitis) is the most commonly used experimental model for studying multiple Sclerosis. The MOG (183-191) peptide can be used to induce an immune response and provoke a demyelination of the CNS (Central Nervous System). MOG183-191 can generate specific anti-MOG 183-191 antibodies. This process leads to an experimental autoimmune encephalomyelitis

Biotin-Ova (323-339) is the N-ter biotinylated version of Ova (323-339). Biotin-Ova (323-339) can be used in the analysis of antigen-specific T cells. Ovalbumin protein: Ova (323-339) is an epitope of interest of the egg white albumen, which is widely used in allergy research. Ovalbumin is a glycoprotein that is sufficiently large and complex to be mildly immunogenic. Indeed, it has been demonstrated that Ovalbumin contains B-cell epitopes which are recognized by specific IgE antibodies and CD4 T cell epitopes restricted by the MHC I-Ad molecule in mice and by HLA-D molecule in human. Applications of Ova (323-339): Ova (323-339) allows to study bindings of class II MHC-peptide and T-cell activation in PBMCs by ELISPOT assays. In fact, this method quantifies peptide epitope specificity and IFN-γ releasing effector cells. It has been shown that Ova (323-339) was responsible for 25-35% of T-cell response of isolated BALB/c mouse. An investigation has demonstrated that Ova and Ova (323-33

Recombinant SARS-CoV-2 Omicron Variant B.1.1.529 Nucleocapsid (N), derived from the transfected human HEK293 cells.