Assays & Kits

PYROGENS & ENDOTOXIN DETECTION AT FUJIFIM PYROGENS ARE FEVER-INDUCING SUBSTANCES THAT IF ADMINISTERED TO HUMANS ABOVE CERTAIN CONCENTRATIONS MAY CAUSE SEVERE INFLAMMATION AND IN SOME CASES EVEN LEAD TO DEATH. WHILE ENDOGENOUS PYROGENS MAINLY CONSIST OF CYTOKINES, EXOGENOUS PYROGENS HAVE SIGNIFICANTLY GREATER STRUCTURAL DIVERSITY, COMPRISING A BROAD RANGE OF DIFFERENT MOLECULES SUCH AS LIPOPOLYSACCHARIDES, GLUCANES OR SMALL ORGANIC COMPOUNDS SUCH AS 2,4-DINITROPHENOL. AMONG EXOGENOUS PYROGENS THE GRAM-NEGATIVE CELL-WALL COMPONENT LIPOPOLYSACCHARIDE (LPS) IS GENERALLY CONSIDERED AS BIOLOGICALLY MOST ACTIVE. LPS CONSIST OF LARGE GLYCOCONJUGATES, INCLUDING A LIPIDIC MOIETY AND A POLYSACCHARIDE CORE TERMED “O-ANTIGEN”. DUE TO THEIR TOXIC PROPERTIES, THEY ARE USUALLY REFERRED TO AS ENDOTOXINS. WHEN ENTERING THE BLOODSTREAM, ENDOTOXINS QUICKLY INTERACT WITH IMMUNE CELLS AND INDUCE STRONG INFLAMMATORY REACTION, RESULTING IN AN INCREASE OF THE BODY TEMPERATURE. OWING TO THEIR GREAT HEAT RESI

ENDOTOXIN EXTRACTING SOLUTION FOR LAL TEST TRADITIONALLY, WATER OR SALINE SOLUTION HAS BEEN USED TO EXTRACT ENDOTOXIN IN TESTS ON MEDICAL DEVICES AND EQUIPMENT; HOWEVER, THE EFFICACY OF THIS EXTRACTION METHOD HAS RECENTLY COME INTO QUESTION. IN ORDER TO PROVIDE OUR CUSTOMERS WITH A MORE RELIABLE METHOD FOR MEDICAL DEVICE TESTING, FUJIFILM WAKO HAS DEVELOPED AN ENDOTOXIN-FREE EXTRACTING SOLUTION CONTAINING HUMAN SERUM ALBUMIN (HSA) THAT IS CAPABLE OF EXTRACTING ENDOTOXINS WHICH CANNOT BE EXTRACTED IN WATER OR SALINE SOLUTION. PRODUCT FEATURES: • CAPABLE OF EXTRACTING ENDOTOXINS FROM SURFACES WHICH CANNOT BE EXTRACTED IN WATER OR SALINE • RECOMMENDED FOR USE IN ENDOTOXIN TESTING ON EQUIPMENT AND DEVICES WHICH MAY COME INTO CONTACT WITH FLUIDS CONTAINING BLOOD OR PROTEIN.

PYROGENS & ENDOTOXIN DETECTION AT FUJIFIM PYROGENS ARE FEVER-INDUCING SUBSTANCES THAT IF ADMINISTERED TO HUMANS ABOVE CERTAIN CONCENTRATIONS MAY CAUSE SEVERE INFLAMMATION AND IN SOME CASES EVEN LEAD TO DEATH. WHILE ENDOGENOUS PYROGENS MAINLY CONSIST OF CYTOKINES, EXOGENOUS PYROGENS HAVE SIGNIFICANTLY GREATER STRUCTURAL DIVERSITY, COMPRISING A BROAD RANGE OF DIFFERENT MOLECULES SUCH AS LIPOPOLYSACCHARIDES, GLUCANES OR SMALL ORGANIC COMPOUNDS SUCH AS 2,4-DINITROPHENOL. AMONG EXOGENOUS PYROGENS THE GRAM-NEGATIVE CELL-WALL COMPONENT LIPOPOLYSACCHARIDE (LPS) IS GENERALLY CONSIDERED AS BIOLOGICALLY MOST ACTIVE. LPS CONSIST OF LARGE GLYCOCONJUGATES, INCLUDING A LIPIDIC MOIETY AND A POLYSACCHARIDE CORE TERMED “O-ANTIGEN”. DUE TO THEIR TOXIC PROPERTIES, THEY ARE USUALLY REFERRED TO AS ENDOTOXINS. WHEN ENTERING THE BLOODSTREAM, ENDOTOXINS QUICKLY INTERACT WITH IMMUNE CELLS AND INDUCE STRONG INFLAMMATORY REACTION, RESULTING IN AN INCREASE OF THE BODY TEMPERATURE. OWING TO THEIR GREAT HEAT RESI

PYROSTAR NEO IS A NEW ENDOTOXIN DETECTION REAGENT DEVELOPED BY RECOMBINANT TECHNOLOGY. COMBINE WITH TRADITIONAL LYSATE REAGENT AND RECOMBINANT 3 FACTORS (FACTOR C, FACTOR B, PROCLOTTING ENZYME) FROM LIMULUS POLYPHEMUS. IT IS A HIGH SENSITIVE COLORIMETRIC ASSAY SPECIFIC FOR ENDOTOXIN.

used for qantifying genomic DNA from CHO cells

PYROGENS & ENDOTOXIN DETECTION AT FUJIFIM PYROGENS ARE FEVER-INDUCING SUBSTANCES THAT IF ADMINISTERED TO HUMANS ABOVE CERTAIN CONCENTRATIONS MAY CAUSE SEVERE INFLAMMATION AND IN SOME CASES EVEN LEAD TO DEATH. WHILE ENDOGENOUS PYROGENS MAINLY CONSIST OF CYTOKINES, EXOGENOUS PYROGENS HAVE SIGNIFICANTLY GREATER STRUCTURAL DIVERSITY, COMPRISING A BROAD RANGE OF DIFFERENT MOLECULES SUCH AS LIPOPOLYSACCHARIDES, GLUCANES OR SMALL ORGANIC COMPOUNDS SUCH AS 2,4-DINITROPHENOL. AMONG EXOGENOUS PYROGENS THE GRAM-NEGATIVE CELL-WALL COMPONENT LIPOPOLYSACCHARIDE (LPS) IS GENERALLY CONSIDERED AS BIOLOGICALLY MOST ACTIVE. LPS CONSIST OF LARGE GLYCOCONJUGATES, INCLUDING A LIPIDIC MOIETY AND A POLYSACCHARIDE CORE TERMED “O-ANTIGEN”. DUE TO THEIR TOXIC PROPERTIES, THEY ARE USUALLY REFERRED TO AS ENDOTOXINS. WHEN ENTERING THE BLOODSTREAM, ENDOTOXINS QUICKLY INTERACT WITH IMMUNE CELLS AND INDUCE STRONG INFLAMMATORY REACTION, RESULTING IN AN INCREASE OF THE BODY TEMPERATURE. OWING TO THEIR GREAT HEAT RESI

Detects and quantitates contaminant DNA in serum and residual DNA in biopharmaceuticals. Employs a new extraction procedure for DNA purification from a single tube. This procedure, using Sodium Iodide (NaI) as a chaotropic agent, realizes DNA isolation of both high quality and high recovery from biological fluids without the use of phenol or chloroform. Complex and laborious manipulations are avoided when using this kit. In addition, this kit has a modified application for use with Molecular Devices' Threshold(TM) System.

The SLP-HS Single Reagent Set II is able to detect both peptidoglycan (PG) and (1->3)-β-D-glucan (BDG). The product uses a self-defense mechanism of silkworm Bombyx mori which leads to a color change by building a black melanin pigment in the presence of microbial contamination. Since PG is found in all bacterial cell walls and BDG in most fungi, the SLP (silkworm larvae plasma)-reagent constitutes a highly sensitive and broadband method for detection of microbial contamination

PYROGENS & ENDOTOXIN DETECTION AT FUJIFIM PYROGENS ARE FEVER-INDUCING SUBSTANCES THAT IF ADMINISTERED TO HUMANS ABOVE CERTAIN CONCENTRATIONS MAY CAUSE SEVERE INFLAMMATION AND IN SOME CASES EVEN LEAD TO DEATH. WHILE ENDOGENOUS PYROGENS MAINLY CONSIST OF CYTOKINES, EXOGENOUS PYROGENS HAVE SIGNIFICANTLY GREATER STRUCTURAL DIVERSITY, COMPRISING A BROAD RANGE OF DIFFERENT MOLECULES SUCH AS LIPOPOLYSACCHARIDES, GLUCANES OR SMALL ORGANIC COMPOUNDS SUCH AS 2,4-DINITROPHENOL. AMONG EXOGENOUS PYROGENS THE GRAM-NEGATIVE CELL-WALL COMPONENT LIPOPOLYSACCHARIDE (LPS) IS GENERALLY CONSIDERED AS BIOLOGICALLY MOST ACTIVE. LPS CONSIST OF LARGE GLYCOCONJUGATES, INCLUDING A LIPIDIC MOIETY AND A POLYSACCHARIDE CORE TERMED “O-ANTIGEN”. DUE TO THEIR TOXIC PROPERTIES, THEY ARE USUALLY REFERRED TO AS ENDOTOXINS. WHEN ENTERING THE BLOODSTREAM, ENDOTOXINS QUICKLY INTERACT WITH IMMUNE CELLS AND INDUCE STRONG INFLAMMATORY REACTION, RESULTING IN AN INCREASE OF THE BODY TEMPERATURE. OWING TO THEIR GREAT HEAT RESI