Lipids

Lysobisphosphatidic acids (LBPAs) known also as bis-(monoacylglycerol)phosphates (BMPs) are specialized lipids reported to play a role in intracellular protein and lipid transport in healthy cells. Their accumulation was observed in pathologic liver tissue and they also serve as antigens for auto-antibody generation in a human autoimmune condition termed antiphospholipid syndrome. Accumulation of LBPAs in intracellular often multilamellar membranes is related to biomembrane polymorphism which may impact intracellular cholesterol transport. (S S) Bisoleoyl-lysobisphosphatidic acid is the naturally occurring biologically active isomer of LPBA. Powered by Bioz See more details on Bioz

3 3'-Bisoleoyl-LBPA ((R R)-3 3’-Bisoleoyl-lysobisphosphatidic acid) is the biologically inactive isomer of LBPA.Lysobisphosphatidic acids (LBPAs) known also as bis-(monoacylglycerol)phosphates (BMPs) are specialized lipids reported to play a role in intracellular protein and lipid transport in healthy cells. Their accumulation was observed in pathologic liver tissue and they also serve as antigens for auto-antibody generation in a human autoimmune condition termed antiphospholipid syndrome. Accumulation of LBPAs in intracellular often multilamellar membranes is related to biomembrane polymorphism which may impact intracellular cholesterol transport.

Biotin-C12-ether LBPA is a biotin conjugate of ether C12 Lysobisphosphatidic acid ((R R)-2 2’-Bisdodecyl-LBPA ammonium salt) an ether analog of the naturally occurring biologically active isomer of LPBA.Lysobisphosphatidic acids (LBPAs) known also as bis-(monoacylglycerol)phosphates (BMPs) are specialized lipid molecules reported to play a role in intracellular protein and lipid transport in healthy cells. Their accumulation was observed in pathologic liver tissue and they also serve as antigens for auto-antibody generation in a human autoimmune condition termed antiphospholipid syndrome. Accumulation of LBPAs in intracellular often multilamellar membranes is related to biomembrane polymorphism which may impact intracellular cholesterol transport.

Cardiolipin (CL) is an important component in prokaryotic and in eukaryotic inner mitochondrial membrane. In humans CL is made by cardiolipin synthase from phosphatidylglycerol and cytidinediphosphatediacylglycerol. Due to its four acyl chains and small head group CL can organize into domains which can be protonsinks fill cavities at protein interfaces stabilize protein oligomers and participate in high-curvature membrane regions. Autoantibodies to CL have been found in patients with anti-phospholipid syndrome and lupus. Amino-CL can be modified with or attached to amine reactive probes/surfaces.

sn-1-Biotin-Labeled Cardiolipin (Biotin-Cardiolipin) can be used in microplate and bead-based assays and affinity experiments. Cardiolipin (CL) is an important component in prokaryotic and in eukaryotic inner mitochondrial membrane. In humans CL is made by cardiolipin synthase from phosphatidylglycerol and cytidinediphosphatediacylglycerol. Due to its four acyl chains and small head group CL can organize into domains which can be protonsinks fill cavities at protein interfaces stabilize protein oligomers and participate in high-curvature membrane regions. Autoantibodies to CL have been found in patients with anti-phospholipid syndrome and lupus.

Fluorescein cardiolipin is a fluorescent analog of cardiolipin labeled at the end of the sn-1 chain.Cardiolipin is an important component in prokaryotic and in eukaryotic inner mitochondrial membrane1. In humans CL is made by cardiolipin synthase from phosphatitydlglycerol and cytidinedisphosphate-diacylglycerdol2. Due to its four acyl chains and small head group CL can organize into domains which can be proton sinks fill cavities at protein interfaces stabilize protein oligomers and participate in high-curvature membrane regions. Autoantibodies to CL have been found in patients with anti-phospholipid syndrome and lupus3.

Cardiolipin (CL) is an important component inprokaryotic and in eukaryotic inner mitochondrial membranes. In humans CL is made by cardiolipin synthase from phosphatidylglycerol and cytidinediphosphate-diacylglycerol. Monolysocardiolipin is an intermediate in CL remodeling and acetyl transferase tafazzin mutations impairing linoleic acid transfer to MCL are considered the main reason of Barth syndrome. Autoantibodies to CL have been found in patients with anti-phospholipid syndrome and lupus. Trispalmitoyl MCL is a stable synthetic analog of this rare and interesting phospholipid.

Cardiolipin (CL) is an important component of the prokaryotic and eukaryotic inner mitochondrial membrane. In humans CL is made by cardiolipin synthase from phosphatidylglycerol and cytidinediphosphate-diacylglycerol. Monolysocardiolipin (MCL) is an intermediate in CL remodeling. Acetyl transferase tafazzin mutations impairing linoleic acid transfer to MCL are considered the main reason of Barth syndrome; and autoantibodies to MCL have been found in patients with anti-phospholipid syndrome and lupus. Fluorescent lipids have been used in TLC electrophoresis microplatefluorescent assays and sub-cellular localization experiments.

Fluorescein Monolysocardiolipin is a fluorescent analog of monolysocardiolipin labeled on the sn-1 acyl chain. Cardiolipin (CL) is an important component of the prokaryotic and eukaryotic inner mitochondrial membrane. In humans CL is made by cardiolipin synthase from phosphatidylglycerol and cytidinediphosphate-diacylglycerol. Monolysocardiolipin (MCL) is an intermediate in CL remodeling. Acetyl transferase tafazzin mutations impairing linoleic acid transfer to MCL are considered the main reason of Barth syndrome; and autoantibodies to MCL have been found in patients with anti-phospholipid syndrome and lupus. Fluorescent lipids have been used in TLC electrophoresis microplatefluorescent assays and sub-cellular localization experiments.