Lipids

sn-1-Biotin-Labeled Monolysocardiolipin (Biotin-monolysocardiolipin) can be used in microplate and bead-based assays and affinity experiments. Cardiolipin (CL) is an important component inprokaryotic and in eukaryotic inner mitochondrial membranes. In humans CL is made by cardiolipin synthase from phosphatidylglycerol and cytidinediphosphate-diacylglycerol. Monolysocardiolipin is an intermediate in CL remodeling and acetyl transferase tafazzin mutations impairing linoleic acid transfer to MCL are considered the main reason of Barth syndrome. Autoantibodies to CL have been found in patients with anti-phospholipid syndrome and lupus.

Glycerophosphoinositol (GroPI) is the building block for phosphoinositide polyphosphates and is a substrate for PI-PLC.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol (PI or PtdIns) is biosynthesized from CDP-diacylglycerol and inositol by phosphatidylinositol synthase. PI is the building block for phosphoinositide polyphosphates through phosphorylation by PI-kinases and is a substrate for PI-PLC yielding diacylgelycerol.Bulk discounts available please email echelon@echelon-inc.com for information.

Phosphatidylinositol diC4 (PI diC4) is a synthetic purified dibutanoyl PI.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol (PI or PtdIns) is biosynthesized from CDP-diacylglycerol and inositol by phosphatidylinositol synthase. PI is the building block for phosphoinositide polyphosphates through phosphorylation by PI-kinases and is a substrate for PI-PLC yielding diacylgelycerol.Alternate Names: Dibutanoyl Phosphatidylinositol PtdIns C4 PI C4 (4:0/4:0) PIBulk discounts available please email echelon@echelon-inc.com for information.Publications Powered by Bioz See more details on Bioz1) Guo J. M. R. Wenk et al. (2003). "Phosphatidylinositol 4-kinase type IIalpha is responsible for the phosphatidylinositol 4-kinase activity associated with synaptic vesicles." Proc Natl Acad Sci U S A 100(7): 3995-4000.2) He F. M. Mao et al. (2004). "Enhancement of phototransduction g protei

Phosphatidylinositol diC8 (PI diC8) is a synthetic purified dioctanoyl PI.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol (PI or PtdIns) is biosynthesized from CDP-diacylglycerol and inositol by phosphatidylinositol synthase. PI is the building block for phosphoinositide polyphosphates through phosphorylation by PI-kinases and is a substrate for PI-PLC yielding diacylgelycerol.Alternate Names: Dioctanoyl Phosphatidylinositol PtdIns C8 PI C8 (8:0/8:0) PIBulk discounts available please email echelon@echelon-inc.com for information.Publications Powered by Bioz See more details on Bioz1) Koharudin L. M. W. Furey et al. (2009). "The phox domain of sorting nexin 5 lacks phosphatidylinositol 3-phosphate (PtdIns(3)P) specificity and preferentially binds to phosphatidylinositol 4 5-bisphosphate (PtdIns(4 5)P2)." J Biol Chem 284(35): 23697-707.

Phosphatidylinositol diC8 (ammonium salt) (PI diC8) is a synthetic purified dioctanoyl PI.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol (PI or PtdIns) is biosynthesized from CDP-diacylglycerol and inositol by phosphatidylinositol synthase. PI is the building block for phosphoinositide polyphosphates through phosphorylation by PI-kinases and is a substrate for PI-PLC yielding diacylgelycerol.Featured in Publications1) Koharudin L. M. W. Furey et al. (2009). "The phox domain of sorting nexin 5 lacks phosphatidylinositol 3-phosphate (PtdIns(3)P) specificity and preferentially binds to phosphatidylinositol 4 5-bisphosphate (PtdIns(4 5)P2)." J Biol Chem 284(35): 23697-707.Alternate Names: Dioctanoyl Phosphatidylinositol PtdIns C8 PI C8 (8:0/8:0) PIBulk discounts available please email echelon@echelon-inc.com for information.

Phosphatidylinositol diC16 (PI diC16) is a synthetic purified dipalmitoyl PI.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol (PI or PtdIns) is biosynthesized from CDP-diacylglycerol and inositol by phosphatidylinositol synthase. PI is the building block for phosphoinositide polyphosphates through phosphorylation by PI-kinases and is a substrate for PI-PLC yielding diacylgelycerol.Alternate Names: Dipalmitoyl Phosphatidylinositol PtdIns C16 or PI C16 (16:0/16:0) PIBulk discounts available please email echelon@echelon-inc.com for information.Publications Powered by Bioz See more details on Bioz1) Barylko B. S. H. Gerber et al. (2001). "A Novel Family of Phosphatidylinositol 4-Kinases Conserved from Yeast to Humans." J Biol Chem 276(11): 7705-7708.2) Honbou K. R. Minakami et al. (2007). "Full-length p40phox structure suggests a basis for regulation mechanism of its membran

1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphoinositol (16:0 LysoPI LPI) is a synthetic purified palmitoyl PI.Lysophospholipids are lipid mediators which elicit a diverse array of cellular responses through activation of phospholipid specific G protein-coupled receptors. Lysophosphatidylinositol (LPI) induces a number of cellular effects through binding to the GPR55 receptor including angiogenesis bone morphogenesis cancer progression and pain. In addition LPI is thought to be a biomarker for certain cancers.

PI(3)P diC4 (Phosphatidylinositol 3-phosphate diC4) is a synthetic purified dibutanoyl PI(3)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3-phosphate is enriched in early endosomes having roles in endosome fusion and receptor sorting and internalization in multivesicular bodies. PI(3)P has also been found at the plasma membrane and is involved in the translocation of the glucose transport protein GLUT4.Product Keywords: Dibutanoyl Phosphatidylinositol 3-phosphate PtdIns(3)P C4 PI(3)P C4 or PI3P C4Bulk discounts available please email echelon@echelon-inc.com for information.Publications Powered by Bioz See more details on Bioz1) Sankaran V. G. D. E. Klein et al. (2001). "High-affinity binding of a fyve domain to phosphatidylinositol 3- phosphate requires intact phospholipid but not fyve domain oligomerization." Biochemistry 40(29): 8581-7.2) Bravo J. D. Karathanassis

PI(3)P diC8 (Phosphatidylinositol 3-phosphate diC8) is a synthetic purified dioctanoyl PI(3)P.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 3-phosphate is enriched in early endosomes having roles in endosome fusion and receptor sorting and internalization in multivesicular bodies. PI(3)P has also been found at the plasma membrane and is involved in the translocation of the glucose transport protein GLUT4.Product Keywords: Dioctanoyl Phosphatidylinositol 3-phosphate PtdIns(3)P C8 PI(3)P C8 or PI3P C8Bulk discounts available please email echelon@echelon-inc.com for information.Publications Powered by Bioz See more details on Bioz1) Mari M. E. Macia et al. (2001). "Role of the FYVE finger and the RUN domain for the subcellular localization of Rabip4." J Biol Chem 276(45): 42501-8.2) Kim S. A. G. S. Taylor et al. (2002). "Myotubularin and MTMR2 phosphatidylinositol 3-pho