Lipids

Ceramide 1-phosphate (C1P) is biosynthesized from ceramide by the intracellular enzyme Ceramide kinase. C1P inhibits cell apoptosis via inhibition of acid sphingomyelinase activity in contrast to ceramide which promotes apoptosis. C1P is important in inflammation activating cytosolic phospholipase A2 alpha and releasing downstream inflammatory mediators. In addition C1P is involved in DNA synthesis mast cell degranulation and neutrophil phagocytosis.

Ceramide 1-phosphate (C1P) is biosynthesized from ceramide by the intracellular enzyme Ceramide kinase. C1P inhibits cell apoptosis via inhibition of acid sphingomyelinase activity in contrast to ceramide which promotes apoptosis. C1P is important in inflammation activating cytosolic phospholipase A2 alpha and releasing downstream inflammatory mediators. In addition C1P is involved in DNA synthesis mast cell degranulation and neutrophil phagocytosis.

Lactosylceramide (LacCer) synthesized from β-glucosylceramide by lactosylceramide synthase in the Golgi is a ubiquitous sphingolipid in mammalian tissue. Lactosylceramide is important in many cellular functions such as cell proliferation migration adhesion and angiogenesis. Increased production of LacCer have been shown to increase levels of reactive oxygen species in cardiomyocites and are implicated in inflammatory pathways. Biotin-Lactosylceramide can be bound to streptavidin coated surfaces such as plates or beads.

PolyPIPosomes are polymerized liposome-like nanoparticles which show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents or coated surfaces.PolyPIPosomes have demonstrated utility in a number of assay formats: -Protein pull-down -Surface Plasmon Resonance -Liposome overlay assayControl PolyPIPosomes are provided as a 1mM total lipid solution without any PIPn for use as a negative control to confirm there is no non-specific binding. Powered by Bioz See more details on Bioz

PolyPIPosomes are polymerized liposome-like nanoparticles (~200 nm) which show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents or coated surfaces.PolyPIPosomes have demonstrated utility in a number of assay formats: Protein pull-down Surface Plasmon Resonance Liposome overlay assayPI PolyPIPosomes are provided as a 1mM total lipid solution containing 5% phosphatidylinositol (PI). Each order of 250 μL or 1 mL of PolyPIPosomes includes 100 μL of Control PolyPIPosomes. Powered by Bioz See more details on Bioz

PolyPIPosomes are polymerized liposome-like nanoparticles (~200 nm) which show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents or coated surfaces.PolyPIPosomes have demonstrated utility in a number of assay formats: Protein pull-down Surface Plasmon Resonance Liposome overlay assayPI(3)P PolyPIPosomes are provided as a 1mM total lipid solution containing 5% PI(3)P. Each order of 250 μL or 1 mL of PolyPIPosomes includes 100 μL of Control PolyPIPosomes. Powered by Bioz See more details on Bioz

PolyPIPosomes are polymerized liposome-like nanoparticles (~200 nm) which show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents or coated surfaces.PolyPIPosomes have demonstrated utility in a number of assay formats: Protein pull-down Surface Plasmon Resonance Liposome overlay assayPI(4)P PolyPIPosomes are provided as a 1mM total lipid solution containing 5% PI(4)P. Each order of 250 μL or 1 mL of PolyPIPosomes includes 100 μL of Control PolyPIPosomes. Powered by Bioz See more details on Bioz

PolyPIPosomes are polymerized liposome-like nanoparticles (~200 nm) which show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents or coated surfaces.PolyPIPosomes have demonstrated utility in a number of assay formats: Protein pull-down Surface Plasmon Resonance Liposome overlay assayPI(5)P PolyPIPosomes are provided as a 1mM total lipid solution containing 5% PI(5)P. Each order of 250 μL or 1 mL of PolyPIPosomes includes 100 μL of Control PolyPIPosomes. Powered by Bioz See more details on Bioz

PolyPIPosomes are polymerized liposome-like nanoparticles (~200 nm) which show markedly increased stability (up to 6 months) vs. conventional liposomes. A biotin tag is incorporated for easy detection of PIPn-binding proteins with streptavidin reagents or coated surfaces.PolyPIPosomes have demonstrated utility in a number of assay formats: Protein pull-down Surface Plasmon Resonance Liposome overlay assayPI(3 4)P2 PolyPIPosomes are provided as a 1mM total lipid solution containing 5% PI(3 4)P2. Each order of 250 μL or 1 mL of PolyPIPosomes includes 100 μL of Control PolyPIPosomes. Powered by Bioz See more details on Bioz