Lipids

SM-102 (Lipid H) is an ionizable lipid used in lipid nanoparticles (LNPs). LNP compositions have proven effective as transport vehicles into cells and/or intracellular compartments for biologically active substances such as small molecule drugs proteins and nucleic acids.This is a reagent grade product for research use only.

ALC-0159 is a PEG/lipid conjugate (i.e. PEGylated lipid), specifically, it is the N,N-dimyristylamide of 2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilodaltons (corresponding to about 45-46 ethylene oxide units per molecule of N,N-dimyristyl hydroxyacetamide). It is a non-ionic surfactant by its nature. It has been deployed in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine that contains the active ingredient tozinameran. Reagent grade, for research use only.

ALC-0159 is a PEGylated lipid which has been used to form lipid nanoparticles for delivery of RNA. ALC-0159 is one of the components in the BNT162b2 vaccine against SARS-CoV-2 in addition to ALC-0315 DSPC and cholesterol. This is a reagent grade product for research use only. Additional information can be found here.References1) R. Tenchov R. Bird A. E. Curtze Q. Zhou (2021) “Lipid Nanoparticles—From Liposomes to mRNA Vaccine Delivery a Landscape of Research Diversity and Advancement” ACS Nano DOI: 10.1021/acsnano.1c04996.2) K.H. Moss P. Popova et al. (2019) “Lipid Nanoparticles for Delivery of Therapeutic RNA Oligonucleotides” Mol. Pharmaceutics 16 2265–2277 DOI: 10.1021/acs.molpharmaceut.8b01290.3) Y. Duan A. Dhar et al. (2020) “A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems” RSC Adv. 10 26777-26791.

DSPE-Azide is an azido phospholipid molecule with a hydrophilic phosphate head connected to two hydrophobic saturated fatty acids by a glycerol molecule. In water, the molecule can orient itself into lipid bilayer and can be used for drug encapsulation, such as drug loaded liposomes or nanoparticles. The molecule can react rapidly with cyclooctyne, such as DBCO/BCN or with terminal alkyne in the presence of Cu Catalyst. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DSPE-MAL is a thiol reactive a phospholipid compound. It has two saturated fatty acids and can self-assemble in water to form lipid bilayer. The molecule can be used to prepare liposomes as drug nanocarrier. The maleimide moiety can react with cysteine or other thiol molecule for bioconjugation. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DPPC, also known as 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine, is a phospholipid containing the 16 carbon fatty acid/palmitic acid (16:0) at the sn-1 and sn-2 positions. It is commonly used in the generation of micelles, liposomes, and other types of artificial membranes. Due to the medium size of fatty acid chain, DLPC is used to form thinner membranes or lipid bilayers. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

DOTAP, 1,2-Dioleoyl-3-trimethylammonium propane is a di-chain, or gemini, cationic surfactant. DOTAP has been used for in vitro and in vivo nucleic acid and protein delivery. Reagent grade, for research use only.

Heparin an anticoagulant drug is widely recognized to be a biologically important and chemically unique polysaccharide. Specifically it is also used in the treatment of heart attacks and unstable angina. Also heparin has wide applications in tissue engineering drug delivery and biological research. Fluorescent labeled heparin is used for tracing heparin administered into a biological system. 

Oleoyl-LPA-d5 is a deuterated analog of 18:1 LPA labeled on the glycerol backbone. Lysophosphatidic Acid (LPA) is a small lysophospholipid involved in diverse cellular processes such as cell proliferation chemotaxis platelet aggregation wound healing angiogenesis tumor invasion and smooth muscle contraction. LPA binds to several G-coupled protein receptors to initiate its biological functions. In cancer LPA primarily promotes cell survival migration and invasion. May contain up to 10% of the 2-acyl isomer due to acyl transfer.