Lipids

C12-200 is a branched-chain ionizable lipidoid with five hydroxyl groups. It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA, siRNA, or self-amplifying RNA (saRNA). The hydroxyl groups enables further derivatization or replacement with other reactive functional groups.

DOTMA is one of the first cationic lipid used for gene transfection. It is an effective transfection agent in vitro and in vivo. DOTMA carries a positive charge on the surface of liposomes which condenses anionic nucleic acids and promotes efficient interactions between the cell membrane and the liposome. Reagent grade, for research use only.

DOPE, also known as 1,2-Dioleoyl-sn-glycero-3-PE or 1,2-DOPE, is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. 1,2-DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery. Reagent grade, for research use only.

DLin-KC2-DMA is an ionizable lipid for siRNA delivery. It was formulated and characterized in SNALP and demonstrated to have in vivo activity at siRNA doses as low as 0.01 mg/kg in rodents and 0.1 mg/kg in nonhuman primates. Reagent grade, for research use only.

BP Lipid 106 is an amino ionizable lipid with ester bonds located at C7 relative to nitrogen. The ethanolamine head can effectively enhance mRNA encapsulation while ester bonds improve tissue clearance. The primary lipid tail contains 11 carbons. The ionizable lipid can be used for mRNA delivery due to its excellent physiochemical properties. Reagent grade, for research purpose.

LP01 (BP-Lipid 215) is a biodegradable ionizable lipid which can reduce liver bioaccumulation significantly compared to levels observed with non-biodegradable ionizable lipids such as MC3. These lipids can form nanoparticles that can encapsulate and deliver siRNA, mRNA, DNA or small molecules into cells. Reagent grade, for research use only.

BP Lipid 216 is an amine lipid which has both ester bonds located adjacent to C7 relative to the nitogen amine. The head contains ethanolamine which can efficiently encapsulate mRNA. The lipid can be used to prepare mRNA nanocarriers with good balance of delivery efficiency and pharmakokinetics as well as rapid lipid clearance profile. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

LNP-102 is a lipid nanoparticle (LNP) formulated with SM-102, DSPC, Cholesterol, and DMG-PEG2000. LNP-102 is formulated at optimal molar ratio for efficient delivery of mRNA-based vaccines.

N'-Boc-N-(Gly-Oleoyl)-Lys Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.