Lipids

DMG-PEG 2000 is a lipid component used in the formulation of lipid nanoparticles (LNPs) for RNA delivery. DMG-PEG 2000 typically makes up a small percentage (0.5-3%) of LNP lipids and its role is to increase the circulatory half-life in vivo.

Lipid OA2 is an ionizable lipid which can form single component lipid nanoparticles (LNPs) for delivery of RNA. Similar to lipid-based transfection reagents like LipofectamineTM pre-formed OA2 vesicles are incubated with RNA then the mixture is directly added cells. OA2 LNPs delivered siRNA to downregulate cytokine signaling 1 (SOCS1) in mouse bone marrow dentritic cells. These SOCS downregulated DCs were used as a vaccine which reduced tumor size in a B16-OVA mouse model.

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C3 Ceramide is a lipid featuring two hydrophobic tails, one saturated and the other unsaturated. Ceramides may be used in developing lipid nanoparticles or liposomes.

C2 Dihydroceramide is a lipid featuring an acetamide and a saturated hydrophobic tail. Ceramides may be used in developing lipid nanoparticles or liposomes.

C4 Ceramide is a lipid featuring two hydrophobic tails, one saturated and the other unsaturated. Ceramides may be used in developing lipid nanoparticles or liposomes.

C4 Dihydroceramide is a lipid featuring two saturated hydrophobic tails. Ceramides may be used in developing lipid nanoparticles or liposomes.

C6 Dihydroceramide is a lipid featuring two saturated hydrophobic tails. Ceramides may be used in developing lipid nanoparticles or liposomes.