Lipids

Biotin-Phosphatidylcholine is a functionalized phosphatidylcholine with biotin conjugated to the sn1 acyl chain.Phosphatidylcholine (PC) is generally the most abundant lipid in animal cell membranes providing structural framework. PC is more common in the outer leaflet where it functions as part of the permeability barrier. PC is also the primary substrate of Phospholipase D enzymes which produce the signaling lipids - phosphatidic acid and lysophosphatidic acid.

Miltefosine is effective against visceral infections of Leishmanis species through inhibiton of cytochrome c oxidase. In addition Miltefosine inhibits CTP:phosphocholine cytidylyltransferase and has anti-metastatic effects.References1) Rivas L. & Luque-Ortega J.R. “Miltefosine (hexadecylphosphocholine) inhibits cytochrome c oxidase in Leishmania donovani promastigotes.” (2007) Antimicrob. Chemother. Agents 51 1327-1332.2) Geilen C.C. Wieder T. Reutter W. “Hexadecylphosphocholine inhibits translocation of CTP: Choline-phosphate cytidylyltransferase in Madin-Darby canine kidney cells.” (1992). J Biol Chem. 267 6719-6724.

1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphocholine (P-lysoPC LPC) is generated through hydrolysis of the sn-2 acyl chain of PC by phospholipase A2. It is a major component of oxidized low-density lipoprotein and is believed to have an important role in inflammatory diseases and atherosclerosis. LysoPC is the substrate for Autotaxin/LysoPLD generating lysophosphatidic acid which has an important role in cell motility.

1-Stearoyl-2-hydroxy-sn-glycero-3-phosphocholine (S-lysoPC LPC) is generated through hydrolysis of the sn-2 acyl chain of PC by phospholipase A2. It is a major component of oxidized low-density lipoprotein and is believed to have an important role in inflammatory diseases and atherosclerosis. LysoPC is the substrate for Autotaxin/LysoPLD generating lysophosphatidic acid which has an important role in cell motility.

1-Linoleoyl-2-hydroxy-sn-glycero-3-phosphocholine (18:2 lyso-PC) is generated through hydrolysis of the sn-2 acyl chain of PC by phospholipase A2. It is a major component of oxidized low-density lipoprotein and is believed to have an important role in inflammatory diseases and atherosclerosis. LysoPC is the substrate for Autotaxin/LysoPLD generating lysophosphatidic acid which has an important role in cell motility.The product contains up to 10-15% of the 2-acyl isomer.

LysoPC is generated through hydrolysis of the sn-2 acyl chain of PC by phospholipase A2. It is a major component of oxidized low-density lipoprotein and is believed to have an important role in inflammatory diseases and atherosclerosis. LysoPC is the substrate for Autotaxin/LysoPLD generating lysophosphatidic acid which has an important role in cell motility. The biotin 18:0 LysoPC analog is biotinylated at the end of the sn-1 acyl chain and can be used for binding to streptavidin-coated surfaces such as beads plates etc.ReferencesMatsumoto T. Kobayashi T. Kamata K. (2007) Role of lysophosphatidylcholine (LPC) in atherosclerosis. Curr. Med. Chem. 14 3209-3220

1-Palmitoyl-2-lauroyl-sn-glycero-3-phosphocholine (PLPC) is a phospholipid with palmitoyl (16:0) and lauryl (12:0) acyl chains. This phosphatidylcholine is useful in the study of lipid membrane stability.Phosphatidylcholine (PC) is generally the most abundant lipid in animal cell membranes providing structural framework.  PC is more common in the outer leaflet where it functions as part of the permeability barrier.  PC is also the primary substrate of Phospholipase D enzymes which produce the signaling lipids phosphatidic acid and lysophosphatidic acid.

1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) is a phospholipid with 16:0 and 18:1 acyl chains. This phosphatidylcholine can be used for liposomes to study the properties of lipid bilayers and other biophysical experiments with phospholipids.Phosphatidylcholine (PC) is generally the most abundant lipid in animal cell membranes providing structural framework. PC is more common in the outer leaflet where it functions as part of the permeability barrier. PC is also the primary substrate of Phospholipase D enzymes which produce the signaling lipids - phosphatidic acid and lysophosphatidic acid. Powered by Bioz See more details on Bioz

1-Stearoyl-2-myristoyl-sn-glycero-3-phosphocholine (SMPC) is a phospholipid with stearoyl and myristoyl acyl chains. This phosphocholine can be used to compose liposomes for the study of membrane bilayers.Phosphatidylcholine (PC) is generally the most abundant lipid in animal cell membranes providing structural framework. PC is more common in the outer leaflet where it functions as part of the permeability barrier. PC is also the primary substrate of Phospholipase D enzymes which produce the signaling lipids - phosphatidic acid and lysophosphatidic acid.