Results for Lipids ( 1086 )
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Campesterol, a phytosterol akin to cholesterol, features a shorter alkyl tail due to a C-24 methyl group. As a C-24 alkyl derivative, its tail and body variances impact the size, mRNA encapsulation efficiency (EE), and transfection efficiency of lipid nanoparticles (LNPs), enhancing its ability to potentially improve gene transfection capabilities.
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Fucosterol, found abundantly in seaweed, exhibits limited flexibility in its tail due to unsaturation of the ethyl group. As a C-24 alkyl derivative, its tail and body variations influence the size, mRNA encapsulation efficiency (EE), and transfection efficiency of lipid nanoparticles (LNPs). This characteristic enhances its potential to improve gene transfection capabilities.
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Brassicasterol, a 28-carbon sterol, is produced by various unicellular algae (phytoplankton) and certain terrestrial plants. Its tail region contains a C-24 methyl analog with one double bond, providing low rigidity. As a C-24 alkyl derivative, its tail and body variations impact the size, mRNA encapsulation efficiency (EE), and transfection efficiency of lipid nanoparticles (LNPs). These structural features influence its potential in gene transfection capabilities.
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Ergosterol, a sterol found in fungal cell membranes, plays a role in maintaining membrane integrity, akin to cholesterol in mammals. It features a moderately rigid C-24 methyl analog with one double bond in the tail region and another in the body region. As a C-24 alkyl derivative, its tail and body variations affect the size, mRNA encapsulation efficiency (EE), and transfection efficiency of lipid nanoparticles (LNPs).
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Dehydroergosterol (DHE), a phytosterol derived from ergostane, contains multiple double bonds at positions 5,6-, 7,8-, 9,11-, and 22,23-, along with a 3beta-hydroxy group. It is a highly rigid C-24 methyl derivative with one double bond in the tail region and two double bonds in the body region. Being a C-24 alkyl derivative, its tail and body variances influence the size, mRNA encapsulation efficiency (EE), and transfection efficiency of lipid nanoparticles (LNPs).