Lipids

CL4H6, an ionizable cationic amino lipid with an apparent pKa of 6.35, has been utilized in creating lipid nanoparticles (LNPs). LNPs incorporating CL4H6 and carrying siRNA for Factor VII reduction in mice's liver levels and tumor-targeting siRNAs for CD45, STAT3, and HIF-1alpha in OS-RC-2 renal cancer mouse xenograft models demonstrate tumor volume reduction.

C14-4, an ionizable cationic lipid with a pKa of 6.5, has been employed in lipid nanoparticles (LNPs) for mRNA delivery. These LNPs, containing C14-4 and mRNA encoding a chimeric antigen receptor (CAR), effectively induce CAR expression in human T cells ex vivo, comparable to electroporation but with less toxicity. Additionally, they exhibit cytotoxicity against Nalm-6 leukemia cells in vitro.

A18-Iso5-2DC18 is an unsaturated ionizable lipid derived from alkylene ketones, can effectively transport mRNA vaccines and trigger the stimulator of interferon genes (STING) pathway for enhanced immune response.

306-N16B is an ionizable lipid that efficiently transports mRNA within lipid nanoparticles (LNPs) to the mouse lung in vivo. Conversely, 306-O12B is designed for targeted mRNA delivery to the mouse liver in vivo.

lipid-like compound for efficient delivery of long mRNAs in vivo

4A3-SC8, a dendrimer lipid with ionizable cationic properties, has found application in formulating lipid nanoparticles (LNPs)

10-Undecenoic acid was used as a starting reagent in the syntheses of Pheromone (11Z)-hexadecenal.

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