Cell Line

The 16HBE140 cell line is derived from human bronchial epithelial cells, which are essential for studying the respiratory epithelium. These cells retain several key characteristics of primary bronchial epithelial cells, including the ability to form tight junctions, express characteristic markers, and exhibit typical epithelial morphology. They are widely used in research focusing on respiratory diseases, drug transport, and toxicology studies, providing a reliable in vitro model to understand bronchial epithelial cell behavior under various conditions. One of the significant applications of 16HBE140 cells is in the investigation of cystic fibrosis (CF), a genetic disorder affecting the respiratory system. These cells express the cystic fibrosis transmembrane conductance regulator (CFTR) protein, making them a valuable tool for studying CF pathophysiology and for screening potential therapeutic agents. Additionally, 16HBE140 cells are utilized in airway inflammation research, given th

The MC38 cell line is a murine model extensively utilized in colorectal carcinoma research. Originating from a colon adenocarcinoma in a C57BL/6 mouse, these cells exhibit a high mutational rate, particularly in the mutanome and neoantigen expression, making them highly sensitive to immune checkpoint inhibitor therapy. Their responsiveness to endogenous CD8+ T cell attacks against neoantigens underscores their value in studying immune interactions within tumor environments, positioning the MC38 model as a pivotal immunoresponsive murine tumor model.

HCC78 is a cell line derived from a primary tumor of a lung adenocarcinoma, specifically a subtype known as mucinous bronchioloalveolar carcinoma. This cell line was established from a male adult patient. HCC78 cells are particularly noted for harboring a unique chromosomal rearrangement involving the ROS1 and SLC34A2 genes, which results in the SLC34A2-ROS1 fusion protein. This fusion protein has been implicated in oncogenic signaling pathways, making HCC78 a valuable model for studying the molecular mechanisms of ROS1 fusion-positive lung cancers and for testing targeted therapies against ROS1.

The HET-1A cell line is derived from the human esophageal epithelium and is used extensively in gastroenterological research. These cells provide a valuable model for studying the physiology and pathology of the esophagus, particularly in the context of esophageal diseases such as Barrett's esophagus and esophageal cancer.

The MIN-6 cell line is a murine pancreatic beta cell line derived from insulinoma. It is commonly used in research to study insulin secretion mechanisms and beta-cell function due to its ability to synthesize and secrete insulin in response to glucose levels. This cell line is particularly valuable because it retains many of the functional characteristics of primary pancreatic beta cells, making it a useful model for diabetes research. MIN-6 cells exhibit glucose-responsive insulin secretion, which is a critical trait for studies focusing on the regulation of insulin release and the cellular responses to varying glucose concentrations. The cells are also used to investigate pancreatic beta-cell proliferation and apoptosis, as well as the role of various genes and environmental factors in these processes. Additionally, MIN-6 cells have been instrumental in testing potential pharmacological agents for their effects on beta-cell function and survival, thus contributing to the development

The SNU-601 cell line is derived from a poorly differentiated human gastric carcinoma and is widely utilized in gastric cancer research. This cell line serves as an important model for investigating the molecular and cellular mechanisms underlying gastric adenocarcinoma, which is a prevalent and often aggressive form of stomach cancer. SNU-601 cells are valuable for studying the genetic and epigenetic alterations associated with gastric cancer, as well as for testing the efficacy of potential therapeutic agents. SNU-601 cells exhibit an epithelial morphology and express markers characteristic of gastric carcinoma, including cytokeratins and carcinoembryonic antigen (CEA).

The HEK293 suspension-adapted cell line is a variant of the human embryonic kidney 293 (HEK293) cells that has been modified to grow in suspension culture rather than adherent culture. This adaptation is significant for industrial applications where large-scale protein production is required. The cells maintain many of the characteristics of the original HEK293 line, including a robust transient transfection efficiency and the ability to post-translationally modify expressed proteins in a manner similar to that of native human cells. These cells are particularly valued in the biotechnology and pharmaceutical industries for the production of recombinant proteins and viruses for gene therapy and vaccine development. The adaptation to suspension culture allows for easier scalability and simplifies the harvesting process, making it more suitable for commercial-scale bioprocessing. The HEK293 suspension-adapted cell line supports various viral production systems, including adenovirus, lent

The BA/F3 cell line, originating from murine pro-B cells of the BALB/c mouse strain, is a cornerstone in drug discovery and development, where BaF3 cells are commonly used to test the efficacy of small molecule inhibitors targeting oncogenic kinases

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