Results for Chemicals ( 2140 )
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Squalene is a naturally occurring triterpenoid synthesized from two molecules of farnesyl diphosphate (FPP) by squalene synthase. Echelon's squalene has been further purified to remove oxidized byproducts.Featured in publications1) Howlader DR Das S Lu T Hu G Varisco DJ Dietz ZK Walton SP Ratnakaram SSK Gardner FM Ernst RK Picking WD and Picking WL (2021) Effect of Two Unique Nanoparticle Formulations on the Efficacy of a Broadly Protective Vaccine Against Pseudomonas Aeruginosa. Front. Pharmacol. 12:706157. doi: 10.3389/fphar.2021.706157
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2 3-Oxidosqualene is an important intermediate in the biosynthesis of membrane sterols being converted to lanosterol by 2 3-oxidosqualene cyclase. The (S)-enantiomer is formed by oxidation of squalene by monooxygenase. 2 3-(R)-oxidosqualene is an inhibitor of lanosterol synthase Powered by Bioz See more details on Bioz
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FKBP12 PROTAC dTAG-13 (dTAG-13) is a heterobifunctional degrader that targets FKBP12F36V with FKBP12F36V expressed in-frame with a protein of interest, and selectively degrades the BET bromodomain transcriptional co-activator BRD4 by bridging BET bromodomains to the E3 ubiquitin ligase CRBN.
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FKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional compound that selectively degrades the BET bromodomain transcriptional co-activator BRD4 by linking BET bromodomains to the E3 ubiquitin ligase CRBN. It also functions as a degrader of FKBP12F36V when FKBP12F36V is expressed in-frame with a targeted protein.
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PROTAC Mcl1 degrader-1 induces the ubiquitination and proteasomal degradation of Mcl-1 by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1 inhibitor S1-6 with μM-range affinity. PROTAC Mcl1 degrader-1, a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM.