Compound Libraries

425 food additives;

A unique collection of 3210 compounds for high-throughput screening and high-content screening,

80 species of cyclic peptide molecules for high-throughput and high-content screening;

A unique collection of 2427 of orally active compounds for high-throughput screening and high-content screening.

Activity: Comprises 12 inhibitors of the various components of the Wnt pathway . Function/Pharmacology: The Wnt/ß-catenin pathway is a multi-component pathway primarily involved in embryonic development, adult tissue homeostasis, and cell proliferation. Wnt proteins (i.e Wnt1, Wnt3a, Wnt5a) mediate extracellular signals that activate Wnt membrane receptors Frizzled and LRP5/6. Once activated, these signals inactivate a ß-catenin degradation complex allowing ß-catenin to translocate to the nucleus where it binds to TCF enabling target gene transcription. Dysfunction in the Wnt/ß-catenin pathway is implicated in various cancers, liver disease, ALS, Alzheimer’s disease, bone disease, and cardiovascular disease.

Activity: Comprises 12 inhibitors of various ion channels involved in pain transmission . Function/Pharmacology: Neuropathic pain is caused by damage or dysfunction to peripheral or central nervous system nerve fibers and is frequently chronic in nature. Persistent increased excitability and spontaneous activity in neurons leads to chronic pain that is difficult to treat. As the perception of pain is frequently transmitted via the activation of various ion channels, pharmacological modulation of these channels offers great therapeutic potential.

Activity: Comprises 6 inhibitors of the polycomb-group proteins . Function/Pharmacology: The polycomb-group proteins consist of two classes: Polycomb repressive complex 1 (PRC1) and polycomb repressive complex 2 (PRC2). PRC1 acts as a histone methyltransferase primarily methylating H3K27me3 while PRC2 is a histone ubiquitin ligase acting on histone H2A. Both have important roles in epigenetic gene regulation and are implicated in various disease states because of their role in cellular proliferation-differentiation balance, metabolism, and the immune response.

Activity: Comprises 5 inhibitors of the various PKC isozymes . Function/Pharmacology: The Protein kinase C family of serine/threonine kinases is involved in many cellular processes including gene transcription, cell growth and proliferation, membrane structure, and various immune responses. The family is divided into three main isozyme categories: Conventional (PKCα, ßI, ßII, γ requiring DAG and Ca2+), Novel (PKCδ, ε, η, Θ requiring just DAG), and atypical (PKCι, ζ requiring neither DAG nor Ca2+).

A unique collection of 1867 compounds with anti-ovarian cancer therapeutic activity, can be used for anti-ovarian cancer drug discovery and pharmacological study;