PEG

Tri(Amino-PEG4-amide)-amine is a polyethylene glycol (PEG)-based linker compound used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

UV Cleavable Biotin-PEG2-Azide, a PEG-based PROTAC linker, enables the synthesis of PROTACs[1].

(S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthetic E3 ligase ligand-linker conjugate developed for PROTAC technology, comprising the (S,R,S)-AHPC-based VHL ligand and a 5-unit PEG linker [1].

This hetero-bifunctional reagent allows to crosslink alkyne (bio-)molecules to compounds bearing primary amines. The NHS ester group will react with primary amines while the azide can undergo click reaction. This linker is often used to introduce azide moieties into amino-oligonucleotides after solid phase synthesis.

This hetero-bifunctional reagent allows to crosslink alkyne (bio-)molecules to compounds bearing primary amines. The NHS ester group will react with primary amines while the azide can undergo click reaction. This linker is often used to introduce azide moieties into amino-oligonucleotides after solid phase synthesis.

DBCO-PEG3-NHS ester is a degradable ADC linker that can be used to synthesize antibody-coupled active molecules.

MPEG-2000-DSPE sodium is a phospholipid PEG conjugate with hydrophilicity and hydrophobicity. It is utilized in liposome synthesis to enhance the hydrophilicity of liposomes, thereby prolonging their circulation in the bloodstream. This compound is commonly employed for the investigation of anticancer and antimalarial agents.

Azido-PEG3-C6-Cl is a PEG-based linker for PROTACs, which connects two essential ligands crucial for PROTAC molecule formation, enabling selective protein degradation via the ubiquitin-proteasome system within cells.