PEG

Tri-GalNAc-PEG3-Azide is a specialized compound designed for lysosomal targeting chimera (LYTAC) research, featuring three asialoglycoprotein receptor (ASGPR) ligands linked by a PEG3 spacer and an azide group for easy conjugation. This compound facilitates efficient internalization into hepatocytes through ASGPR-mediated endocytosis, making it a strategic tool for delivering RNA, Cas9 complexes, or other cargo specifically to liver cells. Additionally, it can be utilized to create LYTACs or to be marked with a dye for tissue imaging applications.

Striated muscle preferentially expressed protein kinase, also known as aortic preferentially expressed protein 1, APEG-1, SPEG and KIAA1297, is a protein that belongs to the protein kinase superfamily and CAMK Ser/Thr protein kinase family. SPEG / APEG-1 contains two fibronectin type-III domains, nine Ig-like (immunoglobulin-like) domains, two protein kinase domains. Isoform 1 of SPEG is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 of SPEG is predominantly expressed in the aorta. Isoform 3 of SPEG appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC. Isoform 3 of SPEG may have a role in regulating the growth and differentiation of arterial smooth muscle cells. Isoform 3 of SPEG is quickly down-regulated in response to vascular injury, when ASMC cells change from a quiescent to a proliferative phenotype.

(2-Pyridyldithio)-PEG4-propargyl is a polyethylene glycol (PEG)-based linker engineered for the synthesis of proteolysis-targeting chimeras (PROTACs) [1].

Acid-C2-PEG4-C2-NHS ester, a PEG-based PROTAC linker, facilitates the synthesis of PROTACs[1].

Aminooxy-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1].

APN-C3-PEG4-azide is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands vital for PROTAC molecule formation. This linker supports selective protein degradation via the cell's ubiquitin-proteasome system.

Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3-unit PEG ADC linker used for synthesizing antibody-drug conjugates (ADCs) [1] and also functions as a PEG-based PROTAC linker for PROTAC synthesis [2].

Azido-PEG4-Val-Cit-PAB-OH is a 4-unit PEG ADC linker and a PEG-based PROTAC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] and PROTACs[2].

Biotin-PEG2-C4-alkyne, a PEG-based linker for PROTACs, connects two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.