PEG

N-(Amino-PEG5)-N-bis(PEG4-acid) is a PEG-based PROTAC linker used for synthesizing PROTACs, consisting of an amino group and two terminal carboxylic acids[1].

The PEG-based PROTAC linker, N-(Azido-PEG2)-N-Boc-PEG3-NHS ester, is suitable for the synthesis of PROTACs[1].

Boc-C1-PEG3-C4-OH is an Alkyl/ether-based PROTAC linker used in the synthesis of PROTACs, characterized by their structure of two distinct ligands tethered by a linker, with one ligand binding to an E3 ubiquitin ligase and the other to the target protein, facilitating targeted protein degradation through the ubiquitin-proteasome system [1].

Boc-PEG4-C2-NHS ester is a PEG-based linker for PROTACs that joins two essential ligands to form PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Pomalidomide-PEG1-C2-N3, a conjugate of an E3 ligase ligand-linker, incorporates the cereblon ligand based on Pomalidomide and a 1-unit PEG linker, commonly used in PROTAC technology. This compound enables the design of the selective CDK6 PROTAC degrader CP-10, which effectively induces CDK6 degradation with a DC50 value of 2.1 nM[1].

Lenalidomide-PEG1-azide is an E3 ligase ligand-linker conjugate that incorporates the cereblon ligand based on Lenalidomide and a linker. It is designed for use in the development of PROTAC BRD4 Degrader-2[1].

m-PEG17-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

(S,R,S)-AHPC-PEG2-acid is a PEG-based linker used in PROTACs, connecting two essential ligands to facilitate selective protein degradation via the ubiquitin-proteasome system within cells.

Synonym: PEG2000-DMG-Alexa fluor 647, DMG-PEG2000-Alexa Fluor 647, AF647-DMG-PEG2000, DMG-PEG2000-Cy5, Cy5-PEG2000-DMG, 1,2-dimyristoyl-rac-glycero-3-polyethylene glycol 2000 Alexa fluor 647 Similar products: Cy5 DMG- PEG2000, SF650 PEG2000-DMG