Nucleotides

Bicyclononyne (BCN) is a stable and one of the most reactive cyclooctynes for copper-free click chemistry. Unlike dibenzocyclooctyne (DBCO), BCN is reactive both to azides (strain-promoted azyde-alkyne cycloaddition, SPAAC) and tetrazines (inverse electron demand Diels-Alder reaction, IEDDA)

Chemical phosphorylation reagent for the synthesis of 5’-phosphorylated oligonucleotides. The reagent contains a DMT group in its structure, which allows oligonucleotide purification on C18-cartridges or by reversed-phase chromatography.

Aminolink phosphoramidite for oligonucleotide synthesis. DMS(O)MT is a special protective group similar to traditional MMT, but designed as an improved alternative to it. DMS(O)MT aminolink is fully compatible with standard coupling, deblock, and purification protocols.

Non-nucleosidic modifier reagent for the synthesis of biotinylated oligos based on a hydroxyprolinol core. This phosphoramidite contains a dimethoxytrityl protective group for the purification of the resulting oligos on C18 cartridges, and reverse phase HPLC.

A compound for the phosphoramidite synthesis of oligonucleotides and the creation of the abasic step in the oligonucleotide sequence.Abasic phosphoramidites are used in DNA and oligonucleotide synthesis.

Spacer phosphoramidite 18 (hexaethylene glycol phosphoramidite) is an amidite reagent for oligonucleotide synthesis. It provides a long hydrophilic linker that can be used for the synthesis of Scorpion-type qPCR probes, for spacing biotin from oligo strand, and for other applications requiring spatial separation of modifier and oligo.

After the condensation of the trebler, three DNA branches begin to grow simultaneously with each step of the synthesis. Deblock of this construct gives rise to DNA containing a branching point. One arm (stem) is attached to the branch point with its 5'-end, and other arms (branches) are attached with their 3'-ends. Reverse amidites can be used to prepare constructs with different branch orientations.

Deoxyinosine is a minor base that is encountered in natural nucleic acids. It forms base pairs with A, C and T/U bases. The modified DNA oligonucleotides containing 2'-deoxyinosine can be synthesized using this phosphoramidite.

rU phosphoramidite is a TBDMS-protected phosphoramidite monomer used as a building block when syntheizing RNA.