Cytokines & Chemokines

Animal-Free Recombinant Human IL-17D (Legacy Tebubio ref. 167AF-27). IL-17D is a disulfide-linked homodimer of two 185 amino acid polypeptide chains. It belongs to the IL-17 family of structurally related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17D has the ability to stimulate the production of IL-6, IL-8 and GM-CSF, and inhibits hemopoiesis of myeloid progenitor cells in colony-forming assays. Recombinant Human IL-17D is a 40.5 kDa disulfide-linked homodimer of two 185 amino acid polypeptide chains.

Animal-Free Recombinant Human IL-17D (Legacy Tebubio ref. 167AF-27). IL-17D is a disulfide-linked homodimer of two 185 amino acid polypeptide chains. It belongs to the IL-17 family of structurally related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17D has the ability to stimulate the production of IL-6, IL-8 and GM-CSF, and inhibits hemopoiesis of myeloid progenitor cells in colony-forming assays. Recombinant Human IL-17D is a 40.5 kDa disulfide-linked homodimer of two 185 amino acid polypeptide chains.

Animal-Free Recombinant Human IL-33 (Legacy Tebubio ref. 167AF-33). Human IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. It binds and signals through the IL-1RL1/ST2 receptor, to activate NF-kappaB and MAP kinases. IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities. Recombinant Human IL-33 is a 17.9 kDa protein containing 159 amino acid residues.

Animal-Free Recombinant Human IL-33 (Legacy Tebubio ref. 167AF-33). Human IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. It binds and signals through the IL-1RL1/ST2 receptor, to activate NF-kappaB and MAP kinases. IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities. Recombinant Human IL-33 is a 17.9 kDa protein containing 159 amino acid residues.

Animal-Free Recombinant Human IL-37 (IL-1F7) (Legacy Tebubio ref. 167AF-39). The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-37 (IL-1F7), which acts as a modulator of the immune response. Reduction of IL-37 synthesis in PBMCs leads to increased production of proinflammatory cytokines including IL-1 alpha, IL-1beta, IL-6 and TNF- alpha. The role of IL-37 as an inhibitor of the innate inflammatory response is also corroborated by the observation that it is highly expressed in synovial tissue from patients with rheumatoid arthritis. Full length IL-37 resides primarily in the cytoplasm, but after activation through cleavage by CASP1, it can translocate to the nucleus where it exerts its activity by direct interaction with SMAD3. Recombinant Human IL-37 is a 19.4 kDa protein consisting of 174 amino acids, corresponding to the mature activated form of IL-37.

Animal-Free Recombinant Human IL-37 (IL-1F7) (Legacy Tebubio ref. 167AF-39). The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-37 (IL-1F7), which acts as a modulator of the immune response. Reduction of IL-37 synthesis in PBMCs leads to increased production of proinflammatory cytokines including IL-1 alpha, IL-1beta, IL-6 and TNF- alpha. The role of IL-37 as an inhibitor of the innate inflammatory response is also corroborated by the observation that it is highly expressed in synovial tissue from patients with rheumatoid arthritis. Full length IL-37 resides primarily in the cytoplasm, but after activation through cleavage by CASP1, it can translocate to the nucleus where it exerts its activity by direct interaction with SMAD3. Recombinant Human IL-37 is a 19.4 kDa protein consisting of 174 amino acids, corresponding to the mature activated form of IL-37.

Animal-Free Human Dendritic Cell Cytokine Package (Legacy Tebubio ref. 167AF-HDC). The Animal-Free Human Dendritic Cell Cytokine Package contains the key components required for the culturing of your human dendritic cells. The package contains the following 2 vials: 100ug Animal-Free Human IL-4 and 100ug Animal-Free Human GM-CSF.

Animal-Free Human Hematopoietic Stem Cell Expansion Cytokine Package (IL-3) (Legacy Tebubio ref. 167AF-HHSC3). The Animal-Free Human Hematopoietic Stem Cell Expansion Cytokine Package contains the key components required for ex vivo human hematopoietic stem cells. The package contains the following 4 vials: 100ug Animal-Free Human Flt3 Ligand, 100ug Animal-Free Human SCF, 100ug Animal-Free Human TPO, and 10ug Animal-Free Human IL-3.

Animal-Free Human Hematopoietic Stem Cell Expansion Cytokine Package (IL-6) (Legacy Tebubio ref. 167AF-HHSC6). The Animal-Free Human Hematopoietic Stem Cell Expansion Cytokine Package contains the key components required for ex vivo human hematopoietic stem cells. The package contains the following 4 vials: 100ug Animal-Free Human Flt3 Ligand, 100ug Animal-Free Human SCF, 100ug Animal-Free Human TPO, and 20ug Animal-Free Human IL-6.