Results for Cell Line ( 2577 )
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Mock TRANSiPORT (G) Cells are one of the SLC transporter expressing cells products and HEK293 cells transiently transfected empty vector for use as a negative control in cell-based assay. The uptake in TRANSiPORT(G) cells expressing the SLC transporter should be compared to that in these Mock cells to judge whether the compound is a substrate for transporter of interest. TRANSiPORT (G) Cells are cryopreserved format, offering flexibility in experimental design, allowing for evaluation of interactions between your drug candidates and the transporter of interest just in 2 days. SLC transporters typically mediate the influx of their substrates into the cells, and therefore, you can determine whether the compound acts as a substrate and/or inhibitor of the transporter by measuring the amount incorporated into the cells. In vitro assays using cell-based systems are described in the ICH M12 Guideline “Drug Interaction Studies” and one vial of TRANSiPORT (G) Cells contains enough cells to ass