Cell Line

Human MATE2K TRANSiPORT (G) Cells are one of the SLC transporter expressing cells and HEK293 cells transiently over-expressing MATE2K (Multidrug and toxin extrusion protein 2, SLC47A2). TRANSiPORT (G) Cells are cryopreserved format, offering flexibility in experimental design, allowing for evaluation of interactions between your drug candidates and the transporter of interest just in 2 days. SLC transporters typically mediate the influx of their substrates into the cells, and therefore, you can determine whether the compound acts as a substrate and/or inhibitor of the transporter by measuring the amount incorporated into the cells. In vitro assays using cell-based systems are described in the ICH M12 Guideline “Drug Interaction Studies” and one vial of TRANSiPORT (G) Cells contains enough cells to assay 1 plate, such as 24 well or 96 well format.

Human OATP1A2 TRANSiPORT (G) Cells are one of the SLC transporter expressing cells and HEK293 cells transiently over-expressing OATP1A2 (Organic anion transporting polypeptide 1A2, SLCO1A2). TRANSiPORT (G) Cells are cryopreserved format, offering flexibility in experimental design, allowing for evaluation of interactions between your drug candidates and the transporter of interest just in 2 days. SLC transporters typically mediate the influx of their substrates into the cells, and therefore, you can determine whether the compound acts as a substrate and/or inhibitor of the transporter by measuring the amount incorporated into the cells. In vitro assays using cell-based systems are described in the ICH M12 Guideline “Drug Interaction Studies” and one vial of TRANSiPORT (G) Cells contains enough cells to assay 1 plate, such as 24 well or 96 well format.

Human OAT4 TRANSiPORT (G) Cells are one of the SLC transporter expressing cells and HEK293 cells transiently over-expressing OAT4 (Organic anion transporter 4, SLC22A11). TRANSiPORT (G) Cells are cryopreserved format, offering flexibility in experimental design, allowing for evaluation of interactions between your drug candidates and the transporter of interest just in 2 days. SLC transporters typically mediate the influx of their substrates into the cells, and therefore, you can determine whether the compound acts as a substrate and/or inhibitor of the transporter by measuring the amount incorporated into the cells. In vitro assays using cell-based systems are described in the ICH M12 Guideline “Drug Interaction Studies” and one vial of TRANSiPORT (G) Cells contains enough cells to assay 1 plate, such as 24 well or 96 well format.

Rat Ntcp TRANSiPORT (G) Cells are one of the SLC transporter expressing cells and HEK293 cells transiently over-expressing Ntcp (Na+-taurocholate cotransporting polypeptide, Slc10a1). TRANSiPORT (G) Cells are cryopreserved format, offering flexibility in experimental design, allowing for evaluation of interactions between your drug candidates and the transporter of interest just in 2 days. SLC transporters typically mediate the influx of their substrates into the cells, and therefore, you can determine whether the compound acts as a substrate and/or inhibitor of the transporter by measuring the amount incorporated into the cells. In vitro assays using cell-based systems are described in the ICH M12 Guideline “Drug Interaction Studies” and one vial of TRANSiPORT (G) Cells contains enough cells to assay 1 plate, such as 24 well or 96 well format.

Rat Oatp1a4 TRANSiPORT (G) Cells are one of the SLC transporter expressing cells and HEK293 cells transiently over-expressing Oatp1a4 (Organic anion transporting polypeptide 1a4, SLCO1a4). TRANSiPORT (G) Cells are cryopreserved format, offering flexibility in experimental design, allowing for evaluation of interactions between your drug candidates and the transporter of interest just in 2 days. SLC transporters typically mediate the influx of their substrates into the cells, and therefore, you can determine whether the compound acts as a substrate and/or inhibitor of the transporter by measuring the amount incorporated into the cells. In vitro assays using cell-based systems are described in the ICH M12 Guideline “Drug Interaction Studies” and one vial of TRANSiPORT (G) Cells contains enough cells to assay 1 plate, such as 24 well or 96 well format.

Rat Oatp1b2 TRANSiPORT (G) Cells are one of the SLC transporter expressing cells and HEK293 cells transiently over-expressing Oatp1b2 (Organic anion transporting polypeptide 1b2, SLCO1b2). TRANSiPORT (G) Cells are cryopreserved format, offering flexibility in experimental design, allowing for evaluation of interactions between your drug candidates and the transporter of interest just in 2 days. SLC transporters typically mediate the influx of their substrates into the cells, and therefore, you can determine whether the compound acts as a substrate and/or inhibitor of the transporter by measuring the amount incorporated into the cells. In vitro assays using cell-based systems are described in the ICH M12 Guideline “Drug Interaction Studies” and one vial of TRANSiPORT (G) Cells contains enough cells to assay 1 plate, such as 24 well or 96 well format.

WM1819 is a human melanoma cell line that displays mesenchymal morphology. This cell line features the specific V600E (Val600Glu) mutation at codon 600 in the BRAF gene. This mutation causes constitutively active kinase activity and activation of MEK and ERK signaling pathway. WM1819 cells produce xenograft tumors when injected into immunocompromised mice.