Chemicals & Small Molecules

BDP FL-PEG5-azide is a PEG linker with an azide group and BDP FL dye moiety. The azide group enables Click Chemistry and BDP FL dye moiety is highly compatible with FAM fluorescence measuring instruments. The hydrophilic PEG spacer arm increases water solubility and a membrane permability. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BDP FL-PEG5-propargyl is a BDP FL linker containing a reactive propargyl group and a hydrophilic PEG spacer arm. The propargyl group allows site-specific conjugation by Click Chemistry and is ideal for conjugation with of antibodies, proteins or probes. The hydrophilic PEG spacer arm can increase water solubility. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

TAMRA acid, mixed isomers, has achieved prominence as a dye for oligonucleotide labeling and automated DNA sequencing applications. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BDP FL DBCO is afluorescent reagent containing a reactive DBCO group, DBCO will react with azide-bearing compounds or biomolecules to form a stable triazole linkage without copper catalyst. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

BDP FL-PEG5-acid is a BDP FL acid linker containing a hydrophilic PEG spacer arm. BDP FL is a green-fluorescent dye and the hydrophilic PEG spacer arm increases water solubility as well as membrane permability. BDP FL dye has several characteristics that make it potentially superior in some applications, including high extinction coefficient, high fluorescence quantum yield, narrow emission bandwidth, red shift in fluorescence emission at high dye concentrations, relatively long excited-state lifetime, etc. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

N-(Azido-PEG3)-N-Fluorescein-PEG3-acid contains azide, fluorescein and carboxylic acid moieties. The azide can react with alkynes in copper-catalyzed Click Chemistry. Fluorescein is a universal dye which is used for dye labeling. The carboxylic acid can react with primary amines in the presence of activators such as EDC and HATU. The hydrophilic PEG linker increases the compounds water solubility in aqueous media. Reagent grade, for research purpose. Please contact us for GMP-grade inquiries.

Resveratrol is a class IA PI3K inhibitor activates SIRT1 and displays antiproliferative effect on human breast epithelial cells. By depolarization of mitochondrial membrane and caspase-9 activation resveratrol induces apoptosis. In addition Resveratrol inhibits ribonucleotide reductase and DNA synthesis cyclooxygenase-1 PKD and eicosanoid synthesis.References1) S Fröjdö et al. Resveratrol is a class IA phosphoinositide 3-kinase inhibitor Biochem J. 406 511 (2007)2) K.T. Howitz et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425 191 (2003)3) O.P. Mgbonyebi et al. Antiproliferative effect of synthetic resveratrol on human breast epithelial cells. Int. J. Oncol. 12 865 (1998)3) J. Dorrie et al. Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells. Cancer Res. 61 4731 (2001)4) M. Fontecave et al. Resveratrol a remarkable inhibitor of ribonucleoti

Trismethoxyresveratrol (3 5 4'-Trimethoxystilbene) induces microtubule disassembly and tubulin depolimerization. it is also a powerful antiangiogenetic agent and inhibits endothelial cell proliferation morphogenesis sprouting and collagen gel invasion.ReferencesM. Belleri et al. Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3 5 4'-trimethoxystilbene. Mol. Pharmacol. 2005 67 1451

2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole (SK1-II) is a cell permeable potent and specific inhibitor of sphingosine kinase (IC50 = 0.5 μM). The compound does not bind to the ATP-binding site and does not affect the kinase activities of hERK2 hPI3K or hPKCα at concentrations up to 60 μM. SK1-II showed anti-tumor properties inducing apoptosis in a number of cell lines including those that express Pgp or MRP1 drug-transport proteins.