Chemicals & Small Molecules

XY-14 is a competitive inhibitor of Lipid Phosphate Phosphatase 1 (LPP1) which is the major enzyme responsible for degrading lysophosphatidic acid (LPA) in platelets. XY-14 (10 μM) inhibits LPP1 in human pulmonary artery endothelial cells preventing the dephosphorylation of sphingosine 1-phosphate (S1P) to sphingosine. XY-14 is also reported to inhibit LPP2 & LPP3 (1).

2R-OMPT is a metabolically-stabilized analog of Lysophosphatidic Acid (LPA) which acts as potent agonist for the LPA3 receptor. Of the two enantiomers (2S)-OMPT is more potent than (2R)-OMPT showing 5-20 fold more activity in calcium release from LPA3-transfected Sf9 and rat hepatoma Rh7777 cells. (2S)-OMPT is also more potent in inducing calcium release IL-6 production and MAPK and Akt phosporylation in OVCAR3 cells. Powered by Bioz See more details on Bioz

OMPT [L-sn-1-O-oleoyl-2-O-methylglyceryl-3-phosphothionate] is a metabolically-stabilized analog of Lysophosphatidic Acid (LPA) which acts as potent agonist for the LPA3 receptor. Of the two enantiomers (2S)-OMPT is more potent than (2R)-OMPT showing 5-20 fold more activity in calcium release from LPA3-transfected Sf9 and rat hepatoma Rh7777 cells. (2S)-OMPT is also more potent in inducing calcium release IL-6 production and MAPK and Akt phosporylation in OVCAR3 cells.

Alkyl-OMPT (D-sn-1-O-oleyl-2-O-methyl-glyceryl-3-phosphothionate) is a potent agonist for the G-protein-coupled LPA 3 receptor. Alkyl OMPT induces cell migration in cancer cells mediated by activation of LPA1. Alkyl OMPT also activated Ca2+ release via LPA2 activation but with reduced potency relative to sn-1-oleoyl LPA. Powered by Bioz See more details on Bioz

PC Lipid Microparticles NBD are beads with attached phosphatidylcholine (PC) and NBD. The headgroups are exposed and available for biological interactions. PC is primarily an extracellular phospholipid of cell membranes and is a key structural lipid. This product is intended for use in apoptosis or phagocytosis studies.Technical Notes1. Total lipid concentration is approximately 1 μmol per 1 mg particles.2. Trace amounts of a fluorescent lipid are embedded in the particles. NBD has maximal excitation/emission at approximately 460/540 nm.3. Particle comprised of a silica core and is 3 µm.

PC/PS Lipid Microparticles NBD are beads with attached phosphatidylcholine (PC) Phosphatidylserine (PS) and NBD. The headgroups are exposed and available for biological interactions. Phosphatidylserine (PS) is an anionic intracellular phospholipid component of the cell membrane and is involved in cell signaling. PC is primarily an extracellular phospholipid of cell membranes and is a key structural lipid. This product is intended for use in apoptosis or phagocytosis studies.Technical Notes1. Total lipid concentration is approximately 1 μmol per 1 mg particles.2. Trace amounts of a fluorescent lipid are embedded in the particles. NBD has maximal excitation/emission at approximately 460/540 nm.3. Particle comprised of a silica core and is 3 µm.

PS Lipid Microparticles NBD are beads with attached Phosphatidylserine (PS) and NBD. The headgroups are exposed and available for biological interactions. Phosphatidylserine (PS) is an anionic intracellular phospholipid component of the cell membrane and is involved in cell signaling. This product is intended for use in apoptosis or phagocytosis studies.Technical Notes1. Total lipid concentration is approximately 1 μmol per 1 mg particles.2. Trace amounts of a fluorescent lipid are embedded in the particles. NBD has maximal excitation/emission at approximately 460/540 nm.3. Particle comprised of a silica core and is 3 µm.

The Collagen Hybridizing Peptides are products of 3-Helix Inc.The collagen hybridizing peptide (CHP) is a novel and unique peptide that specifically binds unfolded collagen chains both in vitro and in vivo [1 2 3]. By sharing the Gly-X-Y repeating sequence of natural collagen CHP has a strong capability to hybridize with denatured collagen chains by reforming the triple helical structure in a fashion similar to DNA fragments annealing to complementary DNA strands. CHP is extremely specific: it has negligible affinity to intact collagen molecules due to lack of binding sites and it is inert towards non-specific binding because of its neutral and hydrophilic nature.CHP is a powerful histopathology tool which enables straightforward detection of inflammation and tissue damage caused by a large variety of diseases as well as tissue remodeling during development and aging [3]. CHP robustly visualizes the pericellular matrix turnover caused by proteolytic migration of cancer cells withi

Propargyl-geraniol ((E E)-3 7-Dimethyl-8-(2-propargyloxy)-2 6-octadien-1-ol) is an alkyne-modified isoprenoid that acts as a chemical reporter of protein prenylation via "Click" chemistry.The alkyne-modified isoprenoids were developed by the Distefano group at the University of Minnesota as chemical reporters of protein prenylation. The isoprenoids readily penetrate mammalian cells and are used as substrates by prenyltransferases. The pendant alkyne can be derivatized with an azide-containing tag such as a fluorophore or biotin via a Cu(I) catalyzed “Click” reaction allowing the prenylated proteins to be identified and quantified.